Ingested insecticide to control Aedes aegypti: developing a novel dried attractive toxic sugar bait device for intra-domiciliary control
Abstract Background Illnesses transmitted by Aedes aegypti (Linnaeus, 1762) such as dengue, chikungunya and Zika comprise a considerable global burden; mosquito control is the primary public health tool to reduce disease transmission. Current interventions are inadequate and insecticide resistance t...
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doaj-c23779be976e4fd4b074842e8d0b4eb52020-11-25T02:11:18ZengBMCParasites & Vectors1756-33052020-02-0113111110.1186/s13071-020-3930-9Ingested insecticide to control Aedes aegypti: developing a novel dried attractive toxic sugar bait device for intra-domiciliary controlRachel Sippy0Galo E. Rivera1Valeria Sanchez2Froilán Heras3Bianca Morejón4Efraín Beltrán5Robert S. Hikida6María A. López-Latorre7Alex Aguirre8Anna M. Stewart-Ibarra9David A. Larsen10Marco Neira11Institute for Global Health & Translational Science, SUNY-Upstate Medical UniversityCenter for Research on Health in Latin America, Pontificia Universidad Católica del EcuadorInstitute for Global Health & Translational Science, SUNY-Upstate Medical UniversityInstitute for Global Health & Translational Science, SUNY-Upstate Medical UniversityCenter for Research on Health in Latin America, Pontificia Universidad Católica del EcuadorUnidad Académica de Ciencias Químicas y de la Salud, Universidad Técnica de MachalaOhio UniversityCenter for Research on Health in Latin America, Pontificia Universidad Católica del EcuadorCenter for Research on Health in Latin America, Pontificia Universidad Católica del EcuadorInstitute for Global Health & Translational Science, SUNY-Upstate Medical UniversityDepartment of Public Health, Syracuse UniversityCenter for Research on Health in Latin America, Pontificia Universidad Católica del EcuadorAbstract Background Illnesses transmitted by Aedes aegypti (Linnaeus, 1762) such as dengue, chikungunya and Zika comprise a considerable global burden; mosquito control is the primary public health tool to reduce disease transmission. Current interventions are inadequate and insecticide resistance threatens the effectiveness of these options. Dried attractive bait stations (DABS) are a novel mechanism to deliver insecticide to Ae. aegypti. The DABS are a high-contrast 28 inch2 surface coated with dried sugar-boric acid solution. Aedes aegypti are attracted to DABS by visual cues only, and the dried sugar solution elicits an ingestion response from Ae. aegypti landing on the surface. The study presents the development of the DABS and tests of their impact on Ae. aegypti mortality in the laboratory and a series of semi-field trials. Methods We conducted multiple series of laboratory and semi-field trials to assess the survivability of Ae. aegypti mosquitoes exposed to the DABS. In the laboratory experiments, we assessed the lethality, the killing mechanism, and the shelf life of the device through controlled experiments. In the semi-field trials, we released laboratory-reared female Ae. aegypti into experimental houses typical of peri-urban tropical communities in South America in three trial series with six replicates each. Laboratory experiments were conducted in Quito, Ecuador, and semi-field experiments were conducted in Machala, Ecuador, an area with abundant wild populations of Ae. aegypti and endemic arboviral transmission. Results In the laboratory, complete lethality was observed after 48 hours regardless of physiological status of the mosquito. The killing mechanism was determined to be through ingestion, as the boric acid disrupted the gut of the mosquito. In experimental houses, total mosquito mortality was greater in the treatment house for all series of experiments (P < 0.0001). Conclusions The DABS devices were effective at killing female Ae. aegypti under a variety of laboratory and semi-field conditions. DABS are a promising intervention for interdomiciliary control of Ae. aegypti and arboviral disease prevention.http://link.springer.com/article/10.1186/s13071-020-3930-9Aedes aegyptiVector controlToxic sugar baitAttractive baitSemi-fieldDengue |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rachel Sippy Galo E. Rivera Valeria Sanchez Froilán Heras Bianca Morejón Efraín Beltrán Robert S. Hikida María A. López-Latorre Alex Aguirre Anna M. Stewart-Ibarra David A. Larsen Marco Neira |
spellingShingle |
Rachel Sippy Galo E. Rivera Valeria Sanchez Froilán Heras Bianca Morejón Efraín Beltrán Robert S. Hikida María A. López-Latorre Alex Aguirre Anna M. Stewart-Ibarra David A. Larsen Marco Neira Ingested insecticide to control Aedes aegypti: developing a novel dried attractive toxic sugar bait device for intra-domiciliary control Parasites & Vectors Aedes aegypti Vector control Toxic sugar bait Attractive bait Semi-field Dengue |
author_facet |
Rachel Sippy Galo E. Rivera Valeria Sanchez Froilán Heras Bianca Morejón Efraín Beltrán Robert S. Hikida María A. López-Latorre Alex Aguirre Anna M. Stewart-Ibarra David A. Larsen Marco Neira |
author_sort |
Rachel Sippy |
title |
Ingested insecticide to control Aedes aegypti: developing a novel dried attractive toxic sugar bait device for intra-domiciliary control |
title_short |
Ingested insecticide to control Aedes aegypti: developing a novel dried attractive toxic sugar bait device for intra-domiciliary control |
title_full |
Ingested insecticide to control Aedes aegypti: developing a novel dried attractive toxic sugar bait device for intra-domiciliary control |
title_fullStr |
Ingested insecticide to control Aedes aegypti: developing a novel dried attractive toxic sugar bait device for intra-domiciliary control |
title_full_unstemmed |
Ingested insecticide to control Aedes aegypti: developing a novel dried attractive toxic sugar bait device for intra-domiciliary control |
title_sort |
ingested insecticide to control aedes aegypti: developing a novel dried attractive toxic sugar bait device for intra-domiciliary control |
publisher |
BMC |
series |
Parasites & Vectors |
issn |
1756-3305 |
publishDate |
2020-02-01 |
description |
Abstract Background Illnesses transmitted by Aedes aegypti (Linnaeus, 1762) such as dengue, chikungunya and Zika comprise a considerable global burden; mosquito control is the primary public health tool to reduce disease transmission. Current interventions are inadequate and insecticide resistance threatens the effectiveness of these options. Dried attractive bait stations (DABS) are a novel mechanism to deliver insecticide to Ae. aegypti. The DABS are a high-contrast 28 inch2 surface coated with dried sugar-boric acid solution. Aedes aegypti are attracted to DABS by visual cues only, and the dried sugar solution elicits an ingestion response from Ae. aegypti landing on the surface. The study presents the development of the DABS and tests of their impact on Ae. aegypti mortality in the laboratory and a series of semi-field trials. Methods We conducted multiple series of laboratory and semi-field trials to assess the survivability of Ae. aegypti mosquitoes exposed to the DABS. In the laboratory experiments, we assessed the lethality, the killing mechanism, and the shelf life of the device through controlled experiments. In the semi-field trials, we released laboratory-reared female Ae. aegypti into experimental houses typical of peri-urban tropical communities in South America in three trial series with six replicates each. Laboratory experiments were conducted in Quito, Ecuador, and semi-field experiments were conducted in Machala, Ecuador, an area with abundant wild populations of Ae. aegypti and endemic arboviral transmission. Results In the laboratory, complete lethality was observed after 48 hours regardless of physiological status of the mosquito. The killing mechanism was determined to be through ingestion, as the boric acid disrupted the gut of the mosquito. In experimental houses, total mosquito mortality was greater in the treatment house for all series of experiments (P < 0.0001). Conclusions The DABS devices were effective at killing female Ae. aegypti under a variety of laboratory and semi-field conditions. DABS are a promising intervention for interdomiciliary control of Ae. aegypti and arboviral disease prevention. |
topic |
Aedes aegypti Vector control Toxic sugar bait Attractive bait Semi-field Dengue |
url |
http://link.springer.com/article/10.1186/s13071-020-3930-9 |
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