Fibrogenic Secretome of Sirtuin 1-Deficient Endothelial Cells: Wnt, Notch and Glycocalyx Rheostat

Fibrogenic Secretome of Sirtuin 1-Deficient Endothelial Cells: Wnt, Notch and Glycocalyx Rheostat

Sirtuins (SIRT) are ubiquitous histone and protein deacetylases and a member of this family, SIRT1, is the best-studied one. Its functions in endothelial cells encompass branching angiogenesis, activation of endothelial nitric oxide synthase, regulation of proapoptotic and proinflammatory pathways,...

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Bibliographic Details
Main Authors: Mark Lipphardt, Hassan Dihazi, Gerhard A. Müller, Michael S. Goligorsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Physiology
Subjects:
endothelial secretome
DKK3
Jagged-1
syndecan-4
fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01325/full

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