Combined effects of lifestyle risk factors on fatty liver index
Abstract Background Factors of lifestyle may have a major impact on liver-related morbidity and mortality. We examined independent and joint effects of lifestyle risk factors on fatty liver index (FLI), a biomarker of hepatic steatosis, in a population-based cross-sectional national health survey. M...
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doaj-c2400ac223f046c085eead04a22ce9852020-11-25T03:38:45ZengBMCBMC Gastroenterology1471-230X2020-04-0120111010.1186/s12876-020-01270-7Combined effects of lifestyle risk factors on fatty liver indexUlla Nivukoski0Markus Niemelä1Aini Bloigu2Risto Bloigu3Mauri Aalto4Tiina Laatikainen5Onni Niemelä6Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and Tampere UniversityDepartment of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and Tampere UniversityCenter for Life Course Health Research, University of OuluInfrastructure for Population Studies, Faculty of Medicine, University of OuluDepartment of Psychiatry, Seinäjoki Central Hospital and Tampere UniversityNational Institute for Health and Welfare (THL)Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and Tampere UniversityAbstract Background Factors of lifestyle may have a major impact on liver-related morbidity and mortality. We examined independent and joint effects of lifestyle risk factors on fatty liver index (FLI), a biomarker of hepatic steatosis, in a population-based cross-sectional national health survey. Methods The study included 12,368 participants (5784 men, 6584 women) aged 25–74 years. Quantitative estimates of alcohol use, smoking, adiposity and physical activity were used to establish a total score of risk factors, with higher scores indicating an unhealthier lifestyle. FLI was calculated based on an algorithm including body mass index, waist circumference, serum gamma-glutamyltransferase and triglycerides. Results The occurrence of FLI ≥ 60% indicating fatty liver increased from 2.4% in men with zero risk factors to 81.9% in those with a total risk score of 7–8 (p < 0.0005 for linear trend) and in women from 0 to 73.5% (p < 0.0005). The most striking individual impacts on the likelihood for FLI above 60% were observed for physical inactivity (p < 0.0005 for both genders) and alcohol consumption (p < 0.0005 for men). Interestingly, coffee consumption was also found to increase with increasing risk factor scores (p < 0.0005 for linear trend in both genders). Conclusions The data indicates that unfavorable combinations of lifestyle risk factors lead to a high likelihood of hepatic steatosis. Use of FLI as a diagnostic tool may benefit the assessment of interventions aimed at maintaining a healthy lifestyle and prevention of liver-related morbidity.http://link.springer.com/article/10.1186/s12876-020-01270-7AlcoholNAFLDObesityPhysical activitySteatosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ulla Nivukoski Markus Niemelä Aini Bloigu Risto Bloigu Mauri Aalto Tiina Laatikainen Onni Niemelä |
spellingShingle |
Ulla Nivukoski Markus Niemelä Aini Bloigu Risto Bloigu Mauri Aalto Tiina Laatikainen Onni Niemelä Combined effects of lifestyle risk factors on fatty liver index BMC Gastroenterology Alcohol NAFLD Obesity Physical activity Steatosis |
author_facet |
Ulla Nivukoski Markus Niemelä Aini Bloigu Risto Bloigu Mauri Aalto Tiina Laatikainen Onni Niemelä |
author_sort |
Ulla Nivukoski |
title |
Combined effects of lifestyle risk factors on fatty liver index |
title_short |
Combined effects of lifestyle risk factors on fatty liver index |
title_full |
Combined effects of lifestyle risk factors on fatty liver index |
title_fullStr |
Combined effects of lifestyle risk factors on fatty liver index |
title_full_unstemmed |
Combined effects of lifestyle risk factors on fatty liver index |
title_sort |
combined effects of lifestyle risk factors on fatty liver index |
publisher |
BMC |
series |
BMC Gastroenterology |
issn |
1471-230X |
publishDate |
2020-04-01 |
description |
Abstract Background Factors of lifestyle may have a major impact on liver-related morbidity and mortality. We examined independent and joint effects of lifestyle risk factors on fatty liver index (FLI), a biomarker of hepatic steatosis, in a population-based cross-sectional national health survey. Methods The study included 12,368 participants (5784 men, 6584 women) aged 25–74 years. Quantitative estimates of alcohol use, smoking, adiposity and physical activity were used to establish a total score of risk factors, with higher scores indicating an unhealthier lifestyle. FLI was calculated based on an algorithm including body mass index, waist circumference, serum gamma-glutamyltransferase and triglycerides. Results The occurrence of FLI ≥ 60% indicating fatty liver increased from 2.4% in men with zero risk factors to 81.9% in those with a total risk score of 7–8 (p < 0.0005 for linear trend) and in women from 0 to 73.5% (p < 0.0005). The most striking individual impacts on the likelihood for FLI above 60% were observed for physical inactivity (p < 0.0005 for both genders) and alcohol consumption (p < 0.0005 for men). Interestingly, coffee consumption was also found to increase with increasing risk factor scores (p < 0.0005 for linear trend in both genders). Conclusions The data indicates that unfavorable combinations of lifestyle risk factors lead to a high likelihood of hepatic steatosis. Use of FLI as a diagnostic tool may benefit the assessment of interventions aimed at maintaining a healthy lifestyle and prevention of liver-related morbidity. |
topic |
Alcohol NAFLD Obesity Physical activity Steatosis |
url |
http://link.springer.com/article/10.1186/s12876-020-01270-7 |
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