F1F0-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation

F1F0-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation

F1F0-ATP synthase inhibitory factor 1 (IF1) inhibits the reverse mode of F1F0-ATP synthase, and therefore protects cellular ATP content at the expense of accelerated loss of mitochondrial membrane potential (ΔΨm). There is considerable variability in IF1 expression and its influence on bioenergetics...

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Bibliographic Details
Main Authors: Helen Tanton, Svetlana Voronina, Anthony Evans, Jane Armstrong, Robert Sutton, David N. Criddle, Lee Haynes, Michael C. Schmid, Fiona Campbell, Eithne Costello, Alexei V. Tepikin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Physiology
Subjects:
pancreatic ductal adenocarcinoma
pancreatic acinar cells
F1F0-ATP synthase inhibitory factor 1
bioenergetics
ATP
mitochondrial membrane potential
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00833/full

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