P2Y12 Receptor Function and Response to Cangrelor in Neonates With Cyanotic Congenital Heart Disease

P2Y12 Receptor Function and Response to Cangrelor in Neonates With Cyanotic Congenital Heart Disease

Shunt thrombosis remains a major cause of morbidity and mortality, especially during the initial palliation for single-ventricle physiology. The authors present evidence that the P2Y12 inhibitor cangrelor may fill a therapeutic void in thromboprophylaxis. They base this theory on results showing tha...

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Bibliographic Details
Main Authors: Elisabeth A. Kaza, MD, Matthew C. Egalka, MD, Hairu Zhou, MS, Jianchun Chen, PhD, Denise Evans, MSHS, Jayne Prats, PhD, Ruizhi Li, PhD, Scott L. Diamond, PhD, Julie A. Vincent, MD, Emile A. Bacha, MD, Thomas G. Diacovo, MD
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:JACC: Basic to Translational Science
Subjects:
antithrombotic
avatar mice
microfluidics
neonates
shunt thrombosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X17301274

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