Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders
Protein arginine methylation is a novel posttranslational modification that plays a pivotal role in a variety of intracellular events, such as signal transduction, protein-protein interaction and transcriptional regulation, either by the direct regulation of protein function or by metabolic products...
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doaj-c25085365f8e4ceeb8b63562e05ab8aa2020-11-24T22:02:58ZengMDPI AGInternational Journal of Molecular Sciences1422-00672012-09-011310123831240010.3390/ijms131012383Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary DisordersDariusz ZakrzewiczAnna ZakrzewiczKlaus T. PreissnerPhilipp MarkartMalgorzata WygreckaProtein arginine methylation is a novel posttranslational modification that plays a pivotal role in a variety of intracellular events, such as signal transduction, protein-protein interaction and transcriptional regulation, either by the direct regulation of protein function or by metabolic products originating from protein arginine methylation that influence nitric oxide (NO)-dependent processes. A growing body of evidence suggests that both mechanisms are implicated in cardiovascular and pulmonary diseases. This review will present and discuss recent research on PRMTs and the methylation of non-histone proteins and its consequences for the pathogenesis of various lung disorders, including lung cancer, pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease and asthma. This article will also highlight novel directions for possible future investigations to evaluate the functional contribution of arginine methylation in lung homeostasis and disease.http://www.mdpi.com/1422-0067/13/10/12383protein arginine methylationPRMTchronic lung disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dariusz Zakrzewicz Anna Zakrzewicz Klaus T. Preissner Philipp Markart Malgorzata Wygrecka |
spellingShingle |
Dariusz Zakrzewicz Anna Zakrzewicz Klaus T. Preissner Philipp Markart Malgorzata Wygrecka Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders International Journal of Molecular Sciences protein arginine methylation PRMT chronic lung disease |
author_facet |
Dariusz Zakrzewicz Anna Zakrzewicz Klaus T. Preissner Philipp Markart Malgorzata Wygrecka |
author_sort |
Dariusz Zakrzewicz |
title |
Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders |
title_short |
Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders |
title_full |
Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders |
title_fullStr |
Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders |
title_full_unstemmed |
Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders |
title_sort |
protein arginine methyltransferases (prmts): promising targets for the treatment of pulmonary disorders |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2012-09-01 |
description |
Protein arginine methylation is a novel posttranslational modification that plays a pivotal role in a variety of intracellular events, such as signal transduction, protein-protein interaction and transcriptional regulation, either by the direct regulation of protein function or by metabolic products originating from protein arginine methylation that influence nitric oxide (NO)-dependent processes. A growing body of evidence suggests that both mechanisms are implicated in cardiovascular and pulmonary diseases. This review will present and discuss recent research on PRMTs and the methylation of non-histone proteins and its consequences for the pathogenesis of various lung disorders, including lung cancer, pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease and asthma. This article will also highlight novel directions for possible future investigations to evaluate the functional contribution of arginine methylation in lung homeostasis and disease. |
topic |
protein arginine methylation PRMT chronic lung disease |
url |
http://www.mdpi.com/1422-0067/13/10/12383 |
work_keys_str_mv |
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