Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders

Protein arginine methylation is a novel posttranslational modification that plays a pivotal role in a variety of intracellular events, such as signal transduction, protein-protein interaction and transcriptional regulation, either by the direct regulation of protein function or by metabolic products...

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Main Authors: Dariusz Zakrzewicz, Anna Zakrzewicz, Klaus T. Preissner, Philipp Markart, Malgorzata Wygrecka
Format: Article
Language:English
Published: MDPI AG 2012-09-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:http://www.mdpi.com/1422-0067/13/10/12383
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spelling doaj-c25085365f8e4ceeb8b63562e05ab8aa2020-11-24T22:02:58ZengMDPI AGInternational Journal of Molecular Sciences1422-00672012-09-011310123831240010.3390/ijms131012383Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary DisordersDariusz ZakrzewiczAnna ZakrzewiczKlaus T. PreissnerPhilipp MarkartMalgorzata WygreckaProtein arginine methylation is a novel posttranslational modification that plays a pivotal role in a variety of intracellular events, such as signal transduction, protein-protein interaction and transcriptional regulation, either by the direct regulation of protein function or by metabolic products originating from protein arginine methylation that influence nitric oxide (NO)-dependent processes. A growing body of evidence suggests that both mechanisms are implicated in cardiovascular and pulmonary diseases. This review will present and discuss recent research on PRMTs and the methylation of non-histone proteins and its consequences for the pathogenesis of various lung disorders, including lung cancer, pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease and asthma. This article will also highlight novel directions for possible future investigations to evaluate the functional contribution of arginine methylation in lung homeostasis and disease.http://www.mdpi.com/1422-0067/13/10/12383protein arginine methylationPRMTchronic lung disease
collection DOAJ
language English
format Article
sources DOAJ
author Dariusz Zakrzewicz
Anna Zakrzewicz
Klaus T. Preissner
Philipp Markart
Malgorzata Wygrecka
spellingShingle Dariusz Zakrzewicz
Anna Zakrzewicz
Klaus T. Preissner
Philipp Markart
Malgorzata Wygrecka
Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders
International Journal of Molecular Sciences
protein arginine methylation
PRMT
chronic lung disease
author_facet Dariusz Zakrzewicz
Anna Zakrzewicz
Klaus T. Preissner
Philipp Markart
Malgorzata Wygrecka
author_sort Dariusz Zakrzewicz
title Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders
title_short Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders
title_full Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders
title_fullStr Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders
title_full_unstemmed Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders
title_sort protein arginine methyltransferases (prmts): promising targets for the treatment of pulmonary disorders
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2012-09-01
description Protein arginine methylation is a novel posttranslational modification that plays a pivotal role in a variety of intracellular events, such as signal transduction, protein-protein interaction and transcriptional regulation, either by the direct regulation of protein function or by metabolic products originating from protein arginine methylation that influence nitric oxide (NO)-dependent processes. A growing body of evidence suggests that both mechanisms are implicated in cardiovascular and pulmonary diseases. This review will present and discuss recent research on PRMTs and the methylation of non-histone proteins and its consequences for the pathogenesis of various lung disorders, including lung cancer, pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease and asthma. This article will also highlight novel directions for possible future investigations to evaluate the functional contribution of arginine methylation in lung homeostasis and disease.
topic protein arginine methylation
PRMT
chronic lung disease
url http://www.mdpi.com/1422-0067/13/10/12383
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