TGF-β2 Induces Gli1 in a Smad3-Dependent Manner Against Cerebral Ischemia/Reperfusion Injury After Isoflurane Post-conditioning in Rats

TGF-β2 Induces Gli1 in a Smad3-Dependent Manner Against Cerebral Ischemia/Reperfusion Injury After Isoflurane Post-conditioning in Rats

Isoflurane (ISO) post-conditioning attenuates cerebral ischemia/reperfusion (I/R) injury, but the underlying mechanism is incompletely elucidated. Transforming growth factor beta (TGF-β) and hedgehog (Hh) signaling pathways govern a wide range of mechanisms in the central nervous system. We aimed to...

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Bibliographic Details
Main Authors: Li Peng, Chengwei Yang, Jiangwen Yin, Mingyue Ge, Sheng Wang, Guixing Zhang, Qingtong Zhang, Feng Xu, Zhigang Dai, Liping Xie, Yan Li, Jun-qiang Si, Ketao Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Neuroscience
Subjects:
TGF-β
Shh
isoflurane
ischemia/reperfusion injury
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00636/full

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