The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis

The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis

Atherosclerosis is a chronic inflammatory disease that is mediated by both the innate and adaptive immune responses. T lymphocytes, that together with B cells are the cellular effectors of the adaptive immune system, are currently endowed with crucial roles in the development and progression of athe...

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Main Authors: Ricardo F. Antunes, Juan Carlos Kaski, Ingrid E. Dumitriu
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2012/464532
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spelling doaj-c258758c547046cead47d87ff76580b92020-11-25T00:54:57ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512012-01-01201210.1155/2012/464532464532The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in AtherosclerosisRicardo F. Antunes0Juan Carlos Kaski1Ingrid E. Dumitriu2Cardiac and Vascular Sciences, Division of Clinical Sciences, St. George's University of London, Cranmer Terrace, London, SW17 0RE, UKCardiac and Vascular Sciences, Division of Clinical Sciences, St. George's University of London, Cranmer Terrace, London, SW17 0RE, UKCardiac and Vascular Sciences, Division of Clinical Sciences, St. George's University of London, Cranmer Terrace, London, SW17 0RE, UKAtherosclerosis is a chronic inflammatory disease that is mediated by both the innate and adaptive immune responses. T lymphocytes, that together with B cells are the cellular effectors of the adaptive immune system, are currently endowed with crucial roles in the development and progression of atherosclerosis. Costimulatory receptors are a class of molecules expressed by T lymphocytes that regulate the activation of T cells and the generation of effector T-cell responses. In this review we present the roles of costimulatory receptors of the tumour necrosis factor receptor (TNFR) superfamily in atherosclerosis and discuss the implications for future therapies that could be used to specifically modulate the immune response of pathogenic T cells in this disease.http://dx.doi.org/10.1155/2012/464532
collection DOAJ
language English
format Article
sources DOAJ
author Ricardo F. Antunes
Juan Carlos Kaski
Ingrid E. Dumitriu
spellingShingle Ricardo F. Antunes
Juan Carlos Kaski
Ingrid E. Dumitriu
The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis
Journal of Biomedicine and Biotechnology
author_facet Ricardo F. Antunes
Juan Carlos Kaski
Ingrid E. Dumitriu
author_sort Ricardo F. Antunes
title The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis
title_short The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis
title_full The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis
title_fullStr The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis
title_full_unstemmed The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis
title_sort role of costimulatory receptors of the tumour necrosis factor receptor family in atherosclerosis
publisher Hindawi Limited
series Journal of Biomedicine and Biotechnology
issn 1110-7243
1110-7251
publishDate 2012-01-01
description Atherosclerosis is a chronic inflammatory disease that is mediated by both the innate and adaptive immune responses. T lymphocytes, that together with B cells are the cellular effectors of the adaptive immune system, are currently endowed with crucial roles in the development and progression of atherosclerosis. Costimulatory receptors are a class of molecules expressed by T lymphocytes that regulate the activation of T cells and the generation of effector T-cell responses. In this review we present the roles of costimulatory receptors of the tumour necrosis factor receptor (TNFR) superfamily in atherosclerosis and discuss the implications for future therapies that could be used to specifically modulate the immune response of pathogenic T cells in this disease.
url http://dx.doi.org/10.1155/2012/464532
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