Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK SignalingSummary

Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK SignalingSummary

Asparaginase (ASNase) causes pancreatitis in approximately 10% of leukemia patients, and the mechanisms underlying this painful complication are not known. ASNase primarily depletes circulating asparagine, and the endogenously expressed enzyme, asparagine synthetase (ASNS), replenishes asparagine. A...

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Bibliographic Details
Main Authors: Amitava Mukherjee, Nayyar Ahmed, Fateema T. Rose, Abraheem N. Ahmad, Tanveer A. Javed, Li Wen, Rita Bottino, Xiangwei Xiao, Michael S. Kilberg, Sohail Z. Husain
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X19301092

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http://www.sciencedirect.com/science/article/pii/S2352345X19301092

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