Pyruvate Dehydrogenase and Pyruvate Dehydrogenase Kinase Expression in Non Small Cell Lung Cancer and Tumor-Associated Stroma

Pyruvate Dehydrogenase and Pyruvate Dehydrogenase Kinase Expression in Non Small Cell Lung Cancer and Tumor-Associated Stroma

Pyruvate dehydrogenase (PDH) catalyzes the conversion of pyruvate to acetyl-coenzyme A, which enters into the Krebs cycle, providing adenosine triphosphate (ATP) to the cell. PDH activity is under the control of pyruvate dehydrogenase kinases (PDKs). Under hypoxic conditions, conversion of pyruvate...

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Bibliographic Details
Main Authors: Michael I. Koukourakis, Alexandra Giatromanolaki, Efthimios Sivridis, Kevin C. Gatter, Adrian L. Harris
Format: Article
Language:English
Published: Elsevier 2005-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
PDH
PDH kinase
lung cancer
stroma
HIF
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800934

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