Insight into the role of TRAIL in liver diseases
TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL has recently been suggested as a potential therapeutic target in hepatocellular...
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doaj-c279960ad73c4b729fe01764d121aeb32021-05-20T07:36:09ZengElsevierBiomedicine & Pharmacotherapy0753-33222019-02-01110641645Insight into the role of TRAIL in liver diseasesWei Jiang0Dong-Bo Wu1Si-Yu Fu2En-Qiang Chen3Hong Tang4Tao-You Zhou5Center of Infectious Diseases, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Wuhou District, Chengdu, Sichuan Province, ChinaCenter of Infectious Diseases, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Wuhou District, Chengdu, Sichuan Province, ChinaCenter of Infectious Diseases, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Wuhou District, Chengdu, Sichuan Province, ChinaCenter of Infectious Diseases, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Wuhou District, Chengdu, Sichuan Province, ChinaCenter of Infectious Diseases, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Wuhou District, Chengdu, Sichuan Province, ChinaCorresponding author.; Center of Infectious Diseases, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Wuhou District, Chengdu, Sichuan Province, ChinaTNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL has recently been suggested as a potential therapeutic target in hepatocellular carcinoma (HCC) because it promotes apoptosis in cancer cells. Furthermore, studies on the role of TRAIL in liver injury have reported that TRAIL plays an essential role in viral hepatitis, fatty liver diseases, etc. However, several contradictory and confounding effects of TRAIL in these liver diseases have not been fully elucidated or placed into perspective. Hence, this review summarizes recent progress in studies on TRAIL, including its role in apoptotic signaling, potential therapeutic applications of TRAIL in HCC, hepatitis virus infection, and liver fibrosis and cirrhosis.http://www.sciencedirect.com/science/article/pii/S0753332218363893ApoptosisHepatocellular carcinomaTRAILLiver disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei Jiang Dong-Bo Wu Si-Yu Fu En-Qiang Chen Hong Tang Tao-You Zhou |
spellingShingle |
Wei Jiang Dong-Bo Wu Si-Yu Fu En-Qiang Chen Hong Tang Tao-You Zhou Insight into the role of TRAIL in liver diseases Biomedicine & Pharmacotherapy Apoptosis Hepatocellular carcinoma TRAIL Liver disease |
author_facet |
Wei Jiang Dong-Bo Wu Si-Yu Fu En-Qiang Chen Hong Tang Tao-You Zhou |
author_sort |
Wei Jiang |
title |
Insight into the role of TRAIL in liver diseases |
title_short |
Insight into the role of TRAIL in liver diseases |
title_full |
Insight into the role of TRAIL in liver diseases |
title_fullStr |
Insight into the role of TRAIL in liver diseases |
title_full_unstemmed |
Insight into the role of TRAIL in liver diseases |
title_sort |
insight into the role of trail in liver diseases |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2019-02-01 |
description |
TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL has recently been suggested as a potential therapeutic target in hepatocellular carcinoma (HCC) because it promotes apoptosis in cancer cells. Furthermore, studies on the role of TRAIL in liver injury have reported that TRAIL plays an essential role in viral hepatitis, fatty liver diseases, etc. However, several contradictory and confounding effects of TRAIL in these liver diseases have not been fully elucidated or placed into perspective. Hence, this review summarizes recent progress in studies on TRAIL, including its role in apoptotic signaling, potential therapeutic applications of TRAIL in HCC, hepatitis virus infection, and liver fibrosis and cirrhosis. |
topic |
Apoptosis Hepatocellular carcinoma TRAIL Liver disease |
url |
http://www.sciencedirect.com/science/article/pii/S0753332218363893 |
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