Recombinant vectors based on porcine adeno-associated viral serotypes transduce the murine and pig retina.
Recombinant adeno-associated viral (AAV) vectors are known to safely and efficiently transduce the retina. Among the various AAV serotypes available, AAV2/5 and 2/8 are the most effective for gene transfer to photoreceptors (PR), which are the most relevant targets for gene therapy of inherited reti...
Main Authors: | Agostina Puppo, Alexander Bello, Anna Manfredi, Giulia Cesi, Elena Marrocco, Michele Della Corte, Settimio Rossi, Massimo Giunti, Maria Laura Bacci, Francesca Simonelli, Enrico Maria Surace, Gary P Kobinger, Alberto Auricchio |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3592811?pdf=render |
Similar Items
-
MicroRNA-restricted transgene expression in the retina.
by: Marianthi Karali, et al.
Published: (2011-01-01) -
Recombinant adeno-associated virus serotype 6 efficiently transduces primary human melanocytes.
by: Hilary M Sheppard, et al.
Published: (2013-01-01) -
Adeno-associated viral vector serotype 5 poorly transduces liver in rat models.
by: Paula S Montenegro-Miranda, et al.
Published: (2013-01-01) -
Correction: Adeno-Associated Viral Vector Serotype 5 Poorly Transduces Liver in Rat Models
by: The Staff
Published: (2014-01-01) -
Correction: Adeno-Associated Viral Vector Serotype 5 Poorly Transduces Liver in Rat Models.
Published: (2014-01-01)