What Do We Know about Opioids and the Kidney?
Evidence suggests a link between opioid use and kidney disease. This review summarizes the known renal manifestations of opioid use including its role in acute and chronic kidney injury. Both the direct and indirect effects of the drug, and the context which leads to the development of renal failure...
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MDPI AG
2017-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/18/1/223 |
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doaj-c27e0755fd4d4bffb7c9c4c341f88d702020-11-24T22:21:23ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-01-0118122310.3390/ijms18010223ijms18010223What Do We Know about Opioids and the Kidney?Mary Mallappallil0Jacob Sabu1Eli A. Friedman2Moro Salifu3Department of Internal Medicine, State University of New York at Downstate, Brooklyn, New York, NY 11203, USADepartment of Internal Medicine, State University of New York at Downstate, Brooklyn, New York, NY 11203, USADepartment of Internal Medicine, State University of New York at Downstate, Brooklyn, New York, NY 11203, USADepartment of Internal Medicine, State University of New York at Downstate, Brooklyn, New York, NY 11203, USAEvidence suggests a link between opioid use and kidney disease. This review summarizes the known renal manifestations of opioid use including its role in acute and chronic kidney injury. Both the direct and indirect effects of the drug, and the context which leads to the development of renal failure, are explored. While commonly used safely for pain control and anesthesia in those with kidney disease, the concerns with respect to side effects and toxicity of opioids are addressed. This is especially relevant with the worldwide increase in the use of opioids for medical and recreational use.http://www.mdpi.com/1422-0067/18/1/223opioidsrenal failurepharmacokinetics |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Mary Mallappallil Jacob Sabu Eli A. Friedman Moro Salifu |
| spellingShingle |
Mary Mallappallil Jacob Sabu Eli A. Friedman Moro Salifu What Do We Know about Opioids and the Kidney? International Journal of Molecular Sciences opioids renal failure pharmacokinetics |
| author_facet |
Mary Mallappallil Jacob Sabu Eli A. Friedman Moro Salifu |
| author_sort |
Mary Mallappallil |
| title |
What Do We Know about Opioids and the Kidney? |
| title_short |
What Do We Know about Opioids and the Kidney? |
| title_full |
What Do We Know about Opioids and the Kidney? |
| title_fullStr |
What Do We Know about Opioids and the Kidney? |
| title_full_unstemmed |
What Do We Know about Opioids and the Kidney? |
| title_sort |
what do we know about opioids and the kidney? |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1422-0067 |
| publishDate |
2017-01-01 |
| description |
Evidence suggests a link between opioid use and kidney disease. This review summarizes the known renal manifestations of opioid use including its role in acute and chronic kidney injury. Both the direct and indirect effects of the drug, and the context which leads to the development of renal failure, are explored. While commonly used safely for pain control and anesthesia in those with kidney disease, the concerns with respect to side effects and toxicity of opioids are addressed. This is especially relevant with the worldwide increase in the use of opioids for medical and recreational use. |
| topic |
opioids renal failure pharmacokinetics |
| url |
http://www.mdpi.com/1422-0067/18/1/223 |
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