Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

• Main Authors: Min-Cheol Kang, Seung-Hong Lee, Won-Woo Lee, Nalae Kang, Eun-A Kim, Seo Young Kim, Dae Ho Lee, Daekyung Kim, You-Jin Jeon
• Format: Article
• Language: English
• Published: Elsevier 2014-11-01
• Series: Journal of Functional Foods
• Subjects: High glucose; Fucoxanthin; Oxidative stress; Zebrafish model
• Online Access: http://www.sciencedirect.com/science/article/pii/S1756464614002916

High glucose induced oxidative stress is implicated in intracellular toxicity in tissue and blood vessel such as oxidative stress, lipid peroxidation, and cell death. In this study, we attempted to investigate protective effects of fucoxanthin isolated from Ishige okamurae against high glucose induced oxidative stress in human umbilical vein endothelial cells (HUVEC) and zebrafish model. The ROS generation, lipid peroxidation and cell death were significantly reduced in both the fucoxanthin treated HUVEC and zebrafish in vivo model, compared to those of both negative controls. This study indicates that fucoxanthin could protect cells and organ injury against oxidative stress induced by high glucose in vitro HUVEC and in vivo zebrafish model.