Peroxisome Proliferator-Activated Receptor Modulation during Metabolic Diseases and Cancers: Master and Minions

Peroxisome Proliferator-Activated Receptor Modulation during Metabolic Diseases and Cancers: Master and Minions

The prevalence of obesity and metabolic diseases (such as type 2 diabetes mellitus, dyslipidaemia, and cardiovascular diseases) has increased in the last decade, in both industrialized and developing countries. This also coincided with our observation of a similar increase in the prevalence of cance...

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Main Authors: Salvatore Giovanni Vitale, Antonio Simone Laganà, Angela Nigro, Valentina Lucia La Rosa, Paola Rossetti, Agnese Maria Chiara Rapisarda, Sandro La Vignera, Rosita Angela Condorelli, Francesco Corrado, Massimo Buscema, Rosario D’Anna
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2016/6517313
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spelling doaj-c283aa6bd1b34d8c9f48bf8cfc32774a2020-11-24T20:48:20ZengHindawi LimitedPPAR Research1687-47571687-47652016-01-01201610.1155/2016/65173136517313Peroxisome Proliferator-Activated Receptor Modulation during Metabolic Diseases and Cancers: Master and MinionsSalvatore Giovanni Vitale0Antonio Simone Laganà1Angela Nigro2Valentina Lucia La Rosa3Paola Rossetti4Agnese Maria Chiara Rapisarda5Sandro La Vignera6Rosita Angela Condorelli7Francesco Corrado8Massimo Buscema9Rosario D’Anna10Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood ‘‘G. Barresi’’, University of Messina, Messina, ItalyUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood ‘‘G. Barresi’’, University of Messina, Messina, ItalyUnit of Diabetology and Endocrino-Metabolic Diseases, Hospital for Emergency Cannizzaro, Catania, ItalyUnit of Psychodiagnostics and Clinical Psychology, University of Catania, Catania, ItalyUnit of Diabetology and Endocrino-Metabolic Diseases, Hospital for Emergency Cannizzaro, Catania, ItalyDepartment of General Surgery and Medical Surgical Specialties, University of Catania, Catania, ItalyDepartment of Clinical and Experimental Medicine-CRAMD (Research Centre of Motor Activity and Metabolic Rehabilitation in Diabetes), University of Catania, Catania, ItalyDepartment of Clinical and Experimental Medicine-CRAMD (Research Centre of Motor Activity and Metabolic Rehabilitation in Diabetes), University of Catania, Catania, ItalyUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood ‘‘G. Barresi’’, University of Messina, Messina, ItalyUnit of Diabetology and Endocrino-Metabolic Diseases, Hospital for Emergency Cannizzaro, Catania, ItalyUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood ‘‘G. Barresi’’, University of Messina, Messina, ItalyThe prevalence of obesity and metabolic diseases (such as type 2 diabetes mellitus, dyslipidaemia, and cardiovascular diseases) has increased in the last decade, in both industrialized and developing countries. This also coincided with our observation of a similar increase in the prevalence of cancers. The aetiology of these diseases is very complex and involves genetic, nutritional, and environmental factors. Much evidence indicates the central role undertaken by peroxisome proliferator-activated receptors (PPARs) in the development of these disorders. Due to the fact that their ligands could become crucial in future target-therapies, PPARs have therefore become the focal point of much research. Based on this evidence, this narrative review was written with the purpose of outlining the effects of PPARs, their actions, and their prospective uses in metabolic diseases and cancers.http://dx.doi.org/10.1155/2016/6517313
collection DOAJ
language English
format Article
sources DOAJ
author Salvatore Giovanni Vitale
Antonio Simone Laganà
Angela Nigro
Valentina Lucia La Rosa
Paola Rossetti
Agnese Maria Chiara Rapisarda
Sandro La Vignera
Rosita Angela Condorelli
Francesco Corrado
Massimo Buscema
Rosario D’Anna
spellingShingle Salvatore Giovanni Vitale
Antonio Simone Laganà
Angela Nigro
Valentina Lucia La Rosa
Paola Rossetti
Agnese Maria Chiara Rapisarda
Sandro La Vignera
Rosita Angela Condorelli
Francesco Corrado
Massimo Buscema
Rosario D’Anna
Peroxisome Proliferator-Activated Receptor Modulation during Metabolic Diseases and Cancers: Master and Minions
PPAR Research
author_facet Salvatore Giovanni Vitale
Antonio Simone Laganà
Angela Nigro
Valentina Lucia La Rosa
Paola Rossetti
Agnese Maria Chiara Rapisarda
Sandro La Vignera
Rosita Angela Condorelli
Francesco Corrado
Massimo Buscema
Rosario D’Anna
author_sort Salvatore Giovanni Vitale
title Peroxisome Proliferator-Activated Receptor Modulation during Metabolic Diseases and Cancers: Master and Minions
title_short Peroxisome Proliferator-Activated Receptor Modulation during Metabolic Diseases and Cancers: Master and Minions
title_full Peroxisome Proliferator-Activated Receptor Modulation during Metabolic Diseases and Cancers: Master and Minions
title_fullStr Peroxisome Proliferator-Activated Receptor Modulation during Metabolic Diseases and Cancers: Master and Minions
title_full_unstemmed Peroxisome Proliferator-Activated Receptor Modulation during Metabolic Diseases and Cancers: Master and Minions
title_sort peroxisome proliferator-activated receptor modulation during metabolic diseases and cancers: master and minions
publisher Hindawi Limited
series PPAR Research
issn 1687-4757
1687-4765
publishDate 2016-01-01
description The prevalence of obesity and metabolic diseases (such as type 2 diabetes mellitus, dyslipidaemia, and cardiovascular diseases) has increased in the last decade, in both industrialized and developing countries. This also coincided with our observation of a similar increase in the prevalence of cancers. The aetiology of these diseases is very complex and involves genetic, nutritional, and environmental factors. Much evidence indicates the central role undertaken by peroxisome proliferator-activated receptors (PPARs) in the development of these disorders. Due to the fact that their ligands could become crucial in future target-therapies, PPARs have therefore become the focal point of much research. Based on this evidence, this narrative review was written with the purpose of outlining the effects of PPARs, their actions, and their prospective uses in metabolic diseases and cancers.
url http://dx.doi.org/10.1155/2016/6517313
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