Serum Osteocalcin as a Diagnostic Biomarker for Primary Osteoporosis in Women
Introduction: Osteoporosis, a major health problem in elderly population, especially in post-menopausal females, is diagnosed basically on clinical suspicion and bone mineral density measurement. Dual energy x-ray absorptiometry (DEXA) scan though a gold standard of diagnosis becomes unfit for sc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6318/14857_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Osteoporosis, a major health problem in elderly
population, especially in post-menopausal females, is diagnosed
basically on clinical suspicion and bone mineral density measurement. Dual energy x-ray absorptiometry (DEXA) scan though
a gold standard of diagnosis becomes unfit for screening purpose
due to its prohibitive cost, unportability and lack of availability of
machine.
Aim: To assess the diagnostic potential of serum osteocalcin
levels in primary osteoporosis.
Materials and Methods: In a case-control study, 82 postmenopausal females, between 40-70 years, were subjected to
measurements of bone mineral density and serum osteocalcin
levels. Based on the results of DEXA scan they were divided into
two: a) Control group and B) Case group. Case group was further
subdivided as Osteopenia and Osteoporosis depending on their
t-scores. Correlation between different BMD grades and the levels
of serum osteocalcin were analysed statistically.
Results: A negative correlation was found between serum osteocalcin levels and BMD grading. Significant association of age and
years since menopause (YSM) was found with serum osteocalcin
levels and BMD. No association of BMI and serum osteocalcin was
observed with BMD. Statistically significant difference between
values of serum osteocalcin in postmenopausal non-osteoporotic
women, post-menopausal women with low bone mass (osteopenia)
and post-menopausal women with osteoporosis were seen.
Conclusion: Serum osteocalcin level measurement can be used
for screening purpose in post-menopausal patients. Subjects can
be further assessed by DEXA scan to, if indicated. |
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| ISSN: | 2249-782X 0973-709X |