Host cell-derived lactate functions as an effector molecule in Neisseria meningitidis microcolony dispersal.
The development of meningococcal disease, caused by the human pathogen Neisseria meningitidis, is preceded by the colonization of the epithelial layer in the nasopharynx. After initial adhesion to host cells meningococci form aggregates, through pilus-pilus interactions, termed microcolonies from wh...
Main Authors: | Sara Sigurlásdóttir, Jakob Engman, Olaspers Sara Eriksson, Sunil D Saroj, Nadezda Zguna, Pilar Lloris-Garcerá, Leopold L Ilag, Ann-Beth Jonsson |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-04-01
|
Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC5383330?pdf=render |
Similar Items
-
Deletion of D-Lactate Dehydrogenase A in Neisseria meningitidis Promotes Biofilm Formation Through Increased Autolysis and Extracellular DNA Release
by: Sara Sigurlásdóttir, et al.
Published: (2019-03-01) -
Commensal Neisseria cinerea impairs Neisseria meningitidis microcolony development and reduces pathogen colonisation of epithelial cells.
by: Rafael Custodio, et al.
Published: (2020-03-01) -
DNA Blocks the Lethal Effect of Human Beta-Defensin 2 Against Neisseria meningitidis
by: Gabriela M. Wassing, et al.
Published: (2021-06-01) -
NafA negatively controls Neisseria meningitidis piliation.
by: Asaomi Kuwae, et al.
Published: (2011-01-01) -
Olfactory nerve--a novel invasion route of Neisseria meningitidis to reach the meninges.
by: Hong Sjölinder, et al.
Published: (2010-01-01)