Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer
Abstract Background Inhibition of nuclear import via Karyopherin beta 1 (Kpnβ1) shows potential as an anti-cancer approach. This study investigated the use of nuclear import inhibitor, INI-43, in combination with cisplatin. Methods Cervical cancer cells were pre-treated with INI-43 before treatment...
Main Authors: | Ru-pin Alicia Chi, Pauline van der Watt, Wei Wei, Michael J. Birrer, Virna D. Leaner |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-02-01
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Series: | BMC Cancer |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12885-021-07819-3 |
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