The Role of Sphingolipids on Innate Immunity to Intestinal Salmonella Infection
Salmonella spp. remains a major public health problem for the whole world. To reduce the use of antimicrobial agents and drug-resistant Salmonella, a better strategy is to explore alternative therapy rather than to discover another antibiotic. Sphingolipid- and cholesterol-enriched lipid microdomain...
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doaj-c28b2648173d4ace9f0cf53f47e710132020-11-25T00:47:54ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-08-01188172010.3390/ijms18081720ijms18081720The Role of Sphingolipids on Innate Immunity to Intestinal Salmonella InfectionFu-Chen Huang0Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanSalmonella spp. remains a major public health problem for the whole world. To reduce the use of antimicrobial agents and drug-resistant Salmonella, a better strategy is to explore alternative therapy rather than to discover another antibiotic. Sphingolipid- and cholesterol-enriched lipid microdomains attract signaling proteins and orchestrate them toward cell signaling and membrane trafficking pathways. Recent studies have highlighted the crucial role of sphingolipids in the innate immunity against infecting pathogens. It is therefore mandatory to exploit the role of the membrane sphingolipids in the innate immunity of intestinal epithelia infected by this pathogen. In the present review, we focus on the role of sphingolipids in the innate immunity of intestinal epithelia against Salmonella infection, including adhesion, autophagy, bactericidal effect, barrier function, membrane trafficking, cytokine and antimicrobial peptide expression. The intervention of sphingolipid-enhanced foods to make our life healthy or pharmacological agents regulating sphingolipids is provided at the end.https://www.mdpi.com/1422-0067/18/8/1720sphingolipidsSalmonellaintestine epitheliainnate immunity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fu-Chen Huang |
spellingShingle |
Fu-Chen Huang The Role of Sphingolipids on Innate Immunity to Intestinal Salmonella Infection International Journal of Molecular Sciences sphingolipids Salmonella intestine epithelia innate immunity |
author_facet |
Fu-Chen Huang |
author_sort |
Fu-Chen Huang |
title |
The Role of Sphingolipids on Innate Immunity to Intestinal Salmonella Infection |
title_short |
The Role of Sphingolipids on Innate Immunity to Intestinal Salmonella Infection |
title_full |
The Role of Sphingolipids on Innate Immunity to Intestinal Salmonella Infection |
title_fullStr |
The Role of Sphingolipids on Innate Immunity to Intestinal Salmonella Infection |
title_full_unstemmed |
The Role of Sphingolipids on Innate Immunity to Intestinal Salmonella Infection |
title_sort |
role of sphingolipids on innate immunity to intestinal salmonella infection |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2017-08-01 |
description |
Salmonella spp. remains a major public health problem for the whole world. To reduce the use of antimicrobial agents and drug-resistant Salmonella, a better strategy is to explore alternative therapy rather than to discover another antibiotic. Sphingolipid- and cholesterol-enriched lipid microdomains attract signaling proteins and orchestrate them toward cell signaling and membrane trafficking pathways. Recent studies have highlighted the crucial role of sphingolipids in the innate immunity against infecting pathogens. It is therefore mandatory to exploit the role of the membrane sphingolipids in the innate immunity of intestinal epithelia infected by this pathogen. In the present review, we focus on the role of sphingolipids in the innate immunity of intestinal epithelia against Salmonella infection, including adhesion, autophagy, bactericidal effect, barrier function, membrane trafficking, cytokine and antimicrobial peptide expression. The intervention of sphingolipid-enhanced foods to make our life healthy or pharmacological agents regulating sphingolipids is provided at the end. |
topic |
sphingolipids Salmonella intestine epithelia innate immunity |
url |
https://www.mdpi.com/1422-0067/18/8/1720 |
work_keys_str_mv |
AT fuchenhuang theroleofsphingolipidsoninnateimmunitytointestinalsalmonellainfection AT fuchenhuang roleofsphingolipidsoninnateimmunitytointestinalsalmonellainfection |
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1725257971634536448 |