Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus

Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus

Author summary Bone mineral density and lean skeletal mass are heritable traits. Here, Medina-Gomez and colleagues perform bivariate GWAS analyses of total body lean mass and bone mass density in children, and show genetic loci with pleiotropic effects on both traits.

Bibliographic Details
Main Authors:	Carolina Medina-Gomez, John P. Kemp, Niki L. Dimou, Eskil Kreiner, Alessandra Chesi, Babette S. Zemel, Klaus Bønnelykke, Cindy G. Boer, Tarunveer S. Ahluwalia, Hans Bisgaard, Evangelos Evangelou, Denise H. M. Heppe, Lynda F. Bonewald, Jeffrey P. Gorski, Mohsen Ghanbari, Serkalem Demissie, Gustavo Duque, Matthew T. Maurano, Douglas P. Kiel, Yi-Hsiang Hsu, Bram C.J. van der Eerden, Cheryl Ackert-Bicknell, Sjur Reppe, Kaare M. Gautvik, Truls Raastad, David Karasik, Jeroen van de Peppel, Vincent W. V. Jaddoe, André G. Uitterlinden, Jonathan H. Tobias, Struan F.A. Grant, Pantelis G. Bagos, David M. Evans, Fernando Rivadeneira
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00108-3

Similar Items

Srebf1 Controls Midbrain Dopaminergic Neurogenesis
by: Enrique M. Toledo, et al.
Published: (2020-05-01)

SREBF1c and SREBF2 gene polymorphisms are associated with acute coronary syndrome and blood lipid levels in Mexican population.
by: Gilberto Vargas-Alarcon, et al.
Published: (2019-01-01)

Regulatory Roles of <i>SREBF1</i> and <i>SREBF2</i> in Lipid Metabolism and Deposition in Two Chinese Representative Fat-Tailed Sheep Breeds
by: Chen Liang, et al.
Published: (2020-07-01)

Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death
by: Kytömäki Leena, et al.
Published: (2008-12-01)

Integrated analysis of DNA-methylation and gene expression using high-dimensional penalized regression: a cohort study on bone mineral density in postmenopausal women
by: Tonje G. Lien, et al.
Published: (2018-03-01)

Statin Treatment Induced a Lipogenic Expression Hierarchical Network Centered by SREBF2 in the Liver
by: Shiyu Song, et al.
Published: (2021-07-01)

Expression of miR-33 from an SREBF2 intron targets the FTO gene in the chicken.
by: Fang Shao, et al.
Published: (2014-01-01)

Single nucleotide polymorphism of SREBF-1 gene associated with an increased risk of endometrial cancer in Chinese women.
by: Chun-Ping Qiu, et al.
Published: (2014-01-01)

Lipocalin 2 serum levels correlate with age and bone turnover biomarkers in healthy subjects but not in postmenopausal osteoporotic women
by: Antonio Maurizi, et al.
Published: (2021-06-01)

Postmenopausal osteoporosis is a musculoskeletal disease with a common genetic trait which responds to strength training: a translational intervention study
by: Ole Kristoffer Olstad, et al.
Published: (2020-05-01)

Metabolic and Immunological Shifts during Mid-to-Late Gestation Influence Maternal Blood Methylation of CPT1A and SREBF1
by: Shilpa Pavethynath, et al.
Published: (2019-03-01)

Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
by: Li-Yan Li, et al.
Published: (2021-07-01)

Effects of polyunsaturated fatty acids from plant oils and algae on milk fat yield and composition are associated with mammary lipogenic and SREBF1 gene expression
by: J. Angulo, et al.
Published: (2012-01-01)

<i>Srebf2</i> Locus Overexpression Reduces Body Weight, Total Cholesterol and Glucose Levels in Mice Fed with Two Different Diets
by: Irene Andrés-Blasco, et al.
Published: (2020-10-01)

Skeletal site-related variation in human trabecular bone transcriptome and signaling.
by: Satya S Varanasi, et al.
Published: (2010-01-01)

Genetic Polymorphism of miR-196a-2 is Associated with Bone Mineral Density (BMD)
by: Irma Karabegović, et al.
Published: (2017-11-01)

The miR-28-5p Targetome Discovery Identified SREBF2 as One of the Mediators of the miR-28-5p Tumor Suppressor Activity in Prostate Cancer Cells
by: Sofia Fazio, et al.
Published: (2020-02-01)

Antibody Tests in Detecting SARS-CoV-2 Infection: A Meta-Analysis
by: Panagiota I. Kontou, et al.
Published: (2020-05-01)

Meta-analysis of haplotype-association studies: comparison of methods and empirical evaluation of the literature
by: Bagos Pantelis G
Published: (2011-01-01)

Data and programs in support of network analysis of genes and their association with diseases
by: Panagiota I. Kontou, et al.
Published: (2016-09-01)

Bone transcriptome sequencing reveals local tissue determinants of bone mineral density
by: Vid Prijatelj, et al.
Published: (2020-10-01)

Plate Tectonic Evolution and Mineral Resource Potential of the Lancang River Zone, Southwestern Yunnan, People's Republic of China
by: Heppe, Klaus
Published: (2005)

Genome-wide association with bone mass and geometry in the Framingham Heart Study
by: Murabito Joanne M, et al.
Published: (2007-09-01)

Team Handball Experts Outperform Recreational Athletes in Hand and Foot Response Inhibition: A Behavioral Study
by: Holger Heppe, et al.
Published: (2019-05-01)

Perceptions of Texas public school superintendents and legislators regarding strategies utilized by superintendents to influence the development of educational policies
by: Bonewald, Gregory Jason
Published: (2013)

Investigation of a variable geometry supersonic diffuser
by: Heppe, R. Richard
Published: (1947)

Individual and Organizational Coping Resources of Counselors who Survived Vicarious Trauma: A Multiple Case Study
by: Heppe, Dale Ray
Published: (2019)

Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
by: John P Kemp, et al.
Published: (2014-06-01)

Off-Court Generic Perceptual-Cognitive Training in Elite Volleyball Athletes: Task-Specific Effects and Levels of Transfer
by: Marie-Therese Fleddermann, et al.
Published: (2019-07-01)

Tensin-3 oppositely regulates bone mesenchymal stromal cell-derived osteogenesis and adipogenesis
by: Shuang Zhang, et al.
Published: (2021-04-01)

Differential expression analysis of osteoarthritic femoral head bone fragments uncovers underlying transcriptomic determinants
by: Vid Prijatelj, et al.
Published: (2020-10-01)

When the position of a stent is incorrect
by: P. Zoboli, et al.
Published: (2013-05-01)

The Slow Depolarization Following Individual Spikes in Thin, Unmyelinated Axons in Mammalian Cortex
by: Morten Raastad
Published: (2019-05-01)

Leveraging data from bivariate genome-wide association meta-analysis to unravel novel pleitropic pathways of bone-muscle crosstalk
by: Katerina Trajanoska, et al.
Published: (2020-10-01)

Identification of gene expression profiles in myocardial infarction: a systematic review and meta-analysis
by: Panagiota Kontou, et al.
Published: (2018-11-01)

New representation of the non-symmetric homogeneous bounded domains in ℂ4 and ℂ5
by: Gr. Tsagas, et al.
Published: (1992-01-01)

Stochastic models of dispersion and mixing in homogeneous turbulence
by: Heppe, Burkhard Manfred Oskar
Published: (1998)

Bioinformatics Education in Greece: A Survey
by: Efrosyni-Alkisti Paraskevopoulou-Kollia, et al.
Published: (2017-04-01)

Stem cell function is conserved during short-term storage of cultured epidermal cell sheets at 12°C.
by: Håkon Ringstad, et al.
Published: (2020-01-01)

Enamel Matrix Derivative Promote Primary Human Pulp Cell Differentiation and Mineralization
by: Elisabeth Aurstad Riksen, et al.
Published: (2014-05-01)