Effect of Vitamin D Supplementation in Early Life on Children’s Growth and Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background: Vitamin D deficiency during pregnancy or infancy is associated with adverse growth in children. No systematic review has been conducted to summarize available evidence on the effect of vitamin D supplementation in pregnancy and infancy on growth and body composition in children. Objectiv...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-02-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6643/13/2/524 |
id |
doaj-c29863e0f12f47af9c77d1f414bca716 |
---|---|
record_format |
Article |
spelling |
doaj-c29863e0f12f47af9c77d1f414bca7162021-02-06T00:04:42ZengMDPI AGNutrients2072-66432021-02-011352452410.3390/nu13020524Effect of Vitamin D Supplementation in Early Life on Children’s Growth and Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsKristine Ma0Shu Qin Wei1Wei Guang Bi2Hope A. Weiler3Shi Wu Wen4CHU Sainte-Justine Research Center, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaCHU Sainte-Justine Research Center, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaCHU Sainte-Justine Research Center, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaSchool of Human Nutrition, McGill University, Montreal, QC H9X 3L9, CanadaOMNI Research Group, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, CanadaBackground: Vitamin D deficiency during pregnancy or infancy is associated with adverse growth in children. No systematic review has been conducted to summarize available evidence on the effect of vitamin D supplementation in pregnancy and infancy on growth and body composition in children. Objective: We aim to summarize the available evidence on the effect of vitamin D supplementation in pregnancy and infancy on child growth and body composition. Method: A systematic review and meta-analysis were performed on the effects of vitamin D supplementation during early life on children’s growth and body composition (bone, lean and fat). A literature search of randomized controlled trials (RCTs) was conducted to identify relevant studies on the effects of vitamin D supplementation during pregnancy and infancy on children’s body composition (bone, lean and fat) in PubMed, EMBASE and Cochrane Library from inception to 31 December 2020. A Cochrane Risk Assessment Tool was used for quality assessment. The comparison was vitamin D supplementation vs. placebo or standard care. Random-effects and fixed-effect meta-analyses were conducted. The effects are presented as mean differences (MDs) or risk ratios (RRs) with 95% confidence intervals (CIs). Results: A total of 3960 participants from eleven randomized controlled trials were eligible for inclusion. Vitamin D supplementation during pregnancy was associated with higher triceps skinfold thickness (mm) (MD 0.33, 95% CI, 0.12, 0.54; I<sup>2</sup> = 34%) in neonates. Vitamin D supplementation during pregnancy or infancy was associated with significantly increased length for age z-score in infants at 1 year of age (MD 0.29, 95% CI, 0.03, 0.54; I<sup>2</sup> = 0%), and was associated with lower body mass index (BMI) (kg/m<sup>2</sup>) (MD −0.19, 95% CI −0.34, −0.04; I<sup>2</sup> = 0%) and body mass index z-score (BMIZ) (MD −0.12, 95% CI −0.21, −0.04; I<sup>2</sup> = 0%) in offspring at 3–6 years of age. Vitamin D supplementation during early life was not observed to be associated with children’s bone, lean or fat mass. Conclusion: Vitamin D supplementation during pregnancy or infancy may be associated with reduced adiposity in childhood. Further large clinical trials of the effects of vitamin D supplementation on childhood body composition are warranted.https://www.mdpi.com/2072-6643/13/2/524Vitamin Dpregnancyinfancyrandomized controlled trialschildhoodbody composition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kristine Ma Shu Qin Wei Wei Guang Bi Hope A. Weiler Shi Wu Wen |
spellingShingle |
Kristine Ma Shu Qin Wei Wei Guang Bi Hope A. Weiler Shi Wu Wen Effect of Vitamin D Supplementation in Early Life on Children’s Growth and Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Nutrients Vitamin D pregnancy infancy randomized controlled trials childhood body composition |
author_facet |
Kristine Ma Shu Qin Wei Wei Guang Bi Hope A. Weiler Shi Wu Wen |
author_sort |
Kristine Ma |
title |
Effect of Vitamin D Supplementation in Early Life on Children’s Growth and Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title_short |
Effect of Vitamin D Supplementation in Early Life on Children’s Growth and Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title_full |
Effect of Vitamin D Supplementation in Early Life on Children’s Growth and Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title_fullStr |
Effect of Vitamin D Supplementation in Early Life on Children’s Growth and Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title_full_unstemmed |
Effect of Vitamin D Supplementation in Early Life on Children’s Growth and Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title_sort |
effect of vitamin d supplementation in early life on children’s growth and body composition: a systematic review and meta-analysis of randomized controlled trials |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-02-01 |
description |
Background: Vitamin D deficiency during pregnancy or infancy is associated with adverse growth in children. No systematic review has been conducted to summarize available evidence on the effect of vitamin D supplementation in pregnancy and infancy on growth and body composition in children. Objective: We aim to summarize the available evidence on the effect of vitamin D supplementation in pregnancy and infancy on child growth and body composition. Method: A systematic review and meta-analysis were performed on the effects of vitamin D supplementation during early life on children’s growth and body composition (bone, lean and fat). A literature search of randomized controlled trials (RCTs) was conducted to identify relevant studies on the effects of vitamin D supplementation during pregnancy and infancy on children’s body composition (bone, lean and fat) in PubMed, EMBASE and Cochrane Library from inception to 31 December 2020. A Cochrane Risk Assessment Tool was used for quality assessment. The comparison was vitamin D supplementation vs. placebo or standard care. Random-effects and fixed-effect meta-analyses were conducted. The effects are presented as mean differences (MDs) or risk ratios (RRs) with 95% confidence intervals (CIs). Results: A total of 3960 participants from eleven randomized controlled trials were eligible for inclusion. Vitamin D supplementation during pregnancy was associated with higher triceps skinfold thickness (mm) (MD 0.33, 95% CI, 0.12, 0.54; I<sup>2</sup> = 34%) in neonates. Vitamin D supplementation during pregnancy or infancy was associated with significantly increased length for age z-score in infants at 1 year of age (MD 0.29, 95% CI, 0.03, 0.54; I<sup>2</sup> = 0%), and was associated with lower body mass index (BMI) (kg/m<sup>2</sup>) (MD −0.19, 95% CI −0.34, −0.04; I<sup>2</sup> = 0%) and body mass index z-score (BMIZ) (MD −0.12, 95% CI −0.21, −0.04; I<sup>2</sup> = 0%) in offspring at 3–6 years of age. Vitamin D supplementation during early life was not observed to be associated with children’s bone, lean or fat mass. Conclusion: Vitamin D supplementation during pregnancy or infancy may be associated with reduced adiposity in childhood. Further large clinical trials of the effects of vitamin D supplementation on childhood body composition are warranted. |
topic |
Vitamin D pregnancy infancy randomized controlled trials childhood body composition |
url |
https://www.mdpi.com/2072-6643/13/2/524 |
work_keys_str_mv |
AT kristinema effectofvitamindsupplementationinearlylifeonchildrensgrowthandbodycompositionasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT shuqinwei effectofvitamindsupplementationinearlylifeonchildrensgrowthandbodycompositionasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT weiguangbi effectofvitamindsupplementationinearlylifeonchildrensgrowthandbodycompositionasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT hopeaweiler effectofvitamindsupplementationinearlylifeonchildrensgrowthandbodycompositionasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT shiwuwen effectofvitamindsupplementationinearlylifeonchildrensgrowthandbodycompositionasystematicreviewandmetaanalysisofrandomizedcontrolledtrials |
_version_ |
1724282657585496064 |