The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease

<p>Abstract</p> <p>The lung responds to a variety of insults in a remarkably consistent fashion but with inconsistent outcomes that vary from complete resolution and return to normal to the destruction of normal architecture and progressive fibrosis. Increasing evidence indicates t...

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Main Authors:	Keane Michael P, Strieter Robert M
Format:	Article
Language:	English
Published:	BMC 2001-10-01
Series:	Respiratory Research
Subjects:	chemokine cytokine fibrosis inflammation lung
Online Access:	http://dx.doi.org/10.1186/rr177

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spelling	doaj-c29c51a4d4524b538a84db6bb97d73f32020-11-25T01:04:43ZengBMCRespiratory Research1465-99212001-10-0131510.1186/rr177The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung diseaseKeane Michael PStrieter Robert M<p>Abstract</p> <p>The lung responds to a variety of insults in a remarkably consistent fashion but with inconsistent outcomes that vary from complete resolution and return to normal to the destruction of normal architecture and progressive fibrosis. Increasing evidence indicates that diffuse lung disease results from an imbalance between the pro-inflammatory and anti-inflammatory mechanisms, with a persistent imbalance that favors pro-inflammatory mediators dictating the development of chronic diffuse lung disease. This review focuses on the mediators that influence this imbalance.</p> http://dx.doi.org/10.1186/rr177chemokinecytokinefibrosisinflammationlung
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Keane Michael P Strieter Robert M
spellingShingle	Keane Michael P Strieter Robert M The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease Respiratory Research chemokine cytokine fibrosis inflammation lung
author_facet	Keane Michael P Strieter Robert M
author_sort	Keane Michael P
title	The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease
title_short	The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease
title_full	The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease
title_fullStr	The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease
title_full_unstemmed	The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease
title_sort	importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease
publisher	BMC
series	Respiratory Research
issn	1465-9921
publishDate	2001-10-01
description	<p>Abstract</p> <p>The lung responds to a variety of insults in a remarkably consistent fashion but with inconsistent outcomes that vary from complete resolution and return to normal to the destruction of normal architecture and progressive fibrosis. Increasing evidence indicates that diffuse lung disease results from an imbalance between the pro-inflammatory and anti-inflammatory mechanisms, with a persistent imbalance that favors pro-inflammatory mediators dictating the development of chronic diffuse lung disease. This review focuses on the mediators that influence this imbalance.</p>
topic	chemokine cytokine fibrosis inflammation lung
url	http://dx.doi.org/10.1186/rr177
work_keys_str_mv	AT keanemichaelp theimportanceofbalancedproinflammatoryandantiinflammatorymechanismsindiffuselungdisease AT strieterrobertm theimportanceofbalancedproinflammatoryandantiinflammatorymechanismsindiffuselungdisease AT keanemichaelp importanceofbalancedproinflammatoryandantiinflammatorymechanismsindiffuselungdisease AT strieterrobertm importanceofbalancedproinflammatoryandantiinflammatorymechanismsindiffuselungdisease
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The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease

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