Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project.
<h4>Introduction</h4>Depression, cardiovascular diseases and diabetes are among the major non-communicable diseases, leading to significant disability and mortality worldwide. These diseases may share environmental and genetic determinants associated with multimorbid patterns. Stressful...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0245475 |
id |
doaj-c29eed0af33b4daa83eb0b48eca923b6 |
---|---|
record_format |
Article |
spelling |
doaj-c29eed0af33b4daa83eb0b48eca923b62021-06-19T04:35:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01161e024547510.1371/journal.pone.0245475Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project.Nicole MarianiAlessandra BorsiniCharlotte A M CecilJanine F FelixSylvain SebertAnnamaria CattaneoEsther WaltonYuri MilaneschiGuy CochraneClara AmidJeena RajanJuliette GiacobbeYolanda SanzAna AgustíTania SorgYann HeraultJouko MiettunenPriyanka ParmarNadia CattaneVincent JaddoeJyrki LötjönenCarme BuisanMiguel A González BallesterGemma PiellaJosep L GelpiFemke LamersBrenda W J H PenninxHenning TiemeierMalte von TottlebenRainer ThielKatharina F HeilMarjo-Riitta JärvelinCarmine ParianteIsabelle M MansuyKarim Lekadir<h4>Introduction</h4>Depression, cardiovascular diseases and diabetes are among the major non-communicable diseases, leading to significant disability and mortality worldwide. These diseases may share environmental and genetic determinants associated with multimorbid patterns. Stressful early-life events are among the primary factors associated with the development of mental and physical diseases. However, possible causative mechanisms linking early life stress (ELS) with psycho-cardio-metabolic (PCM) multi-morbidity are not well understood. This prevents a full understanding of causal pathways towards the shared risk of these diseases and the development of coordinated preventive and therapeutic interventions.<h4>Methods and analysis</h4>This paper describes the study protocol for EarlyCause, a large-scale and inter-disciplinary research project funded by the European Union's Horizon 2020 research and innovation programme. The project takes advantage of human longitudinal birth cohort data, animal studies and cellular models to test the hypothesis of shared mechanisms and molecular pathways by which ELS shapes an individual's physical and mental health in adulthood. The study will research in detail how ELS converts into biological signals embedded simultaneously or sequentially in the brain, the cardiovascular and metabolic systems. The research will mainly focus on four biological processes including possible alterations of the epigenome, neuroendocrine system, inflammatome, and the gut microbiome. Life-course models will integrate the role of modifying factors as sex, socioeconomics, and lifestyle with the goal to better identify groups at risk as well as inform promising strategies to reverse the possible mechanisms and/or reduce the impact of ELS on multi-morbidity development in high-risk individuals. These strategies will help better manage the impact of multi-morbidity on human health and the associated risk.https://doi.org/10.1371/journal.pone.0245475 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicole Mariani Alessandra Borsini Charlotte A M Cecil Janine F Felix Sylvain Sebert Annamaria Cattaneo Esther Walton Yuri Milaneschi Guy Cochrane Clara Amid Jeena Rajan Juliette Giacobbe Yolanda Sanz Ana Agustí Tania Sorg Yann Herault Jouko Miettunen Priyanka Parmar Nadia Cattane Vincent Jaddoe Jyrki Lötjönen Carme Buisan Miguel A González Ballester Gemma Piella Josep L Gelpi Femke Lamers Brenda W J H Penninx Henning Tiemeier Malte von Tottleben Rainer Thiel Katharina F Heil Marjo-Riitta Järvelin Carmine Pariante Isabelle M Mansuy Karim Lekadir |
spellingShingle |
Nicole Mariani Alessandra Borsini Charlotte A M Cecil Janine F Felix Sylvain Sebert Annamaria Cattaneo Esther Walton Yuri Milaneschi Guy Cochrane Clara Amid Jeena Rajan Juliette Giacobbe Yolanda Sanz Ana Agustí Tania Sorg Yann Herault Jouko Miettunen Priyanka Parmar Nadia Cattane Vincent Jaddoe Jyrki Lötjönen Carme Buisan Miguel A González Ballester Gemma Piella Josep L Gelpi Femke Lamers Brenda W J H Penninx Henning Tiemeier Malte von Tottleben Rainer Thiel Katharina F Heil Marjo-Riitta Järvelin Carmine Pariante Isabelle M Mansuy Karim Lekadir Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project. PLoS ONE |
author_facet |
Nicole Mariani Alessandra Borsini Charlotte A M Cecil Janine F Felix Sylvain Sebert Annamaria Cattaneo Esther Walton Yuri Milaneschi Guy Cochrane Clara Amid Jeena Rajan Juliette Giacobbe Yolanda Sanz Ana Agustí Tania Sorg Yann Herault Jouko Miettunen Priyanka Parmar Nadia Cattane Vincent Jaddoe Jyrki Lötjönen Carme Buisan Miguel A González Ballester Gemma Piella Josep L Gelpi Femke Lamers Brenda W J H Penninx Henning Tiemeier Malte von Tottleben Rainer Thiel Katharina F Heil Marjo-Riitta Järvelin Carmine Pariante Isabelle M Mansuy Karim Lekadir |
author_sort |
Nicole Mariani |
title |
Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project. |
title_short |
Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project. |
title_full |
Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project. |
title_fullStr |
Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project. |
title_full_unstemmed |
Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project. |
title_sort |
identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: the earlycause project. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2021-01-01 |
description |
<h4>Introduction</h4>Depression, cardiovascular diseases and diabetes are among the major non-communicable diseases, leading to significant disability and mortality worldwide. These diseases may share environmental and genetic determinants associated with multimorbid patterns. Stressful early-life events are among the primary factors associated with the development of mental and physical diseases. However, possible causative mechanisms linking early life stress (ELS) with psycho-cardio-metabolic (PCM) multi-morbidity are not well understood. This prevents a full understanding of causal pathways towards the shared risk of these diseases and the development of coordinated preventive and therapeutic interventions.<h4>Methods and analysis</h4>This paper describes the study protocol for EarlyCause, a large-scale and inter-disciplinary research project funded by the European Union's Horizon 2020 research and innovation programme. The project takes advantage of human longitudinal birth cohort data, animal studies and cellular models to test the hypothesis of shared mechanisms and molecular pathways by which ELS shapes an individual's physical and mental health in adulthood. The study will research in detail how ELS converts into biological signals embedded simultaneously or sequentially in the brain, the cardiovascular and metabolic systems. The research will mainly focus on four biological processes including possible alterations of the epigenome, neuroendocrine system, inflammatome, and the gut microbiome. Life-course models will integrate the role of modifying factors as sex, socioeconomics, and lifestyle with the goal to better identify groups at risk as well as inform promising strategies to reverse the possible mechanisms and/or reduce the impact of ELS on multi-morbidity development in high-risk individuals. These strategies will help better manage the impact of multi-morbidity on human health and the associated risk. |
url |
https://doi.org/10.1371/journal.pone.0245475 |
work_keys_str_mv |
AT nicolemariani identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT alessandraborsini identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT charlotteamcecil identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT janineffelix identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT sylvainsebert identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT annamariacattaneo identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT estherwalton identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT yurimilaneschi identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT guycochrane identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT claraamid identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT jeenarajan identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT juliettegiacobbe identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT yolandasanz identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT anaagusti identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT taniasorg identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT yannherault identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT joukomiettunen identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT priyankaparmar identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT nadiacattane identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT vincentjaddoe identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT jyrkilotjonen identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT carmebuisan identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT miguelagonzalezballester identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT gemmapiella identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT joseplgelpi identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT femkelamers identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT brendawjhpenninx identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT henningtiemeier identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT maltevontottleben identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT rainerthiel identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT katharinafheil identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT marjoriittajarvelin identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT carminepariante identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT isabellemmansuy identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject AT karimlekadir identifyingcausativemechanismslinkingearlylifestresstopsychocardiometabolicmultimorbiditytheearlycauseproject |
_version_ |
1721372158899257344 |