Impact of Increased Astrocyte Expression of IL-6, CCL2 or CXCL10 in Transgenic Mice on Hippocampal Synaptic Function
An important aspect of CNS disease and injury is the elevated expression of neuroimmune factors. These factors are thought to contribute to processes ranging from recovery and repair to pathology. The complexity of the CNS and the multitude of neuroimmune factors that are expressed in the CNS during...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2016-06-01
|
Series: | Brain Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/2076-3425/6/2/19 |
id |
doaj-c2a3cee43b044b91a95857294f2ba69e |
---|---|
record_format |
Article |
spelling |
doaj-c2a3cee43b044b91a95857294f2ba69e2020-11-25T00:19:00ZengMDPI AGBrain Sciences2076-34252016-06-01621910.3390/brainsci6020019brainsci6020019Impact of Increased Astrocyte Expression of IL-6, CCL2 or CXCL10 in Transgenic Mice on Hippocampal Synaptic FunctionDonna L. Gruol0Molecular and Cellular Neuroscience Department, The Scripps Research Institute, La Jolla, CA 92037, USAAn important aspect of CNS disease and injury is the elevated expression of neuroimmune factors. These factors are thought to contribute to processes ranging from recovery and repair to pathology. The complexity of the CNS and the multitude of neuroimmune factors that are expressed in the CNS during disease and injury is a challenge to an understanding of the consequences of the elevated expression relative to CNS function. One approach to address this issue is the use of transgenic mice that express elevated levels of a specific neuroimmune factor in the CNS by a cell type that normally produces it. This approach can provide basic information about the actions of specific neuroimmune factors and can contribute to an understanding of more complex conditions when multiple neuroimmune factors are expressed. This review summarizes studies using transgenic mice that express elevated levels of IL-6, CCL2 or CXCL10 through increased astrocyte expression. The studies focus on the effects of these neuroimmune factors on synaptic function at the Schaffer collateral to CA1 pyramidal neuron synapse of the hippocampus, a brain region that plays a key role in cognitive function.http://www.mdpi.com/2076-3425/6/2/19pyramidal neuronsSchaffer collateralsLTPneuroimmunealcoholfield potential recordingscytokinechemokine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Donna L. Gruol |
spellingShingle |
Donna L. Gruol Impact of Increased Astrocyte Expression of IL-6, CCL2 or CXCL10 in Transgenic Mice on Hippocampal Synaptic Function Brain Sciences pyramidal neurons Schaffer collaterals LTP neuroimmune alcohol field potential recordings cytokine chemokine |
author_facet |
Donna L. Gruol |
author_sort |
Donna L. Gruol |
title |
Impact of Increased Astrocyte Expression of IL-6, CCL2 or CXCL10 in Transgenic Mice on Hippocampal Synaptic Function |
title_short |
Impact of Increased Astrocyte Expression of IL-6, CCL2 or CXCL10 in Transgenic Mice on Hippocampal Synaptic Function |
title_full |
Impact of Increased Astrocyte Expression of IL-6, CCL2 or CXCL10 in Transgenic Mice on Hippocampal Synaptic Function |
title_fullStr |
Impact of Increased Astrocyte Expression of IL-6, CCL2 or CXCL10 in Transgenic Mice on Hippocampal Synaptic Function |
title_full_unstemmed |
Impact of Increased Astrocyte Expression of IL-6, CCL2 or CXCL10 in Transgenic Mice on Hippocampal Synaptic Function |
title_sort |
impact of increased astrocyte expression of il-6, ccl2 or cxcl10 in transgenic mice on hippocampal synaptic function |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2016-06-01 |
description |
An important aspect of CNS disease and injury is the elevated expression of neuroimmune factors. These factors are thought to contribute to processes ranging from recovery and repair to pathology. The complexity of the CNS and the multitude of neuroimmune factors that are expressed in the CNS during disease and injury is a challenge to an understanding of the consequences of the elevated expression relative to CNS function. One approach to address this issue is the use of transgenic mice that express elevated levels of a specific neuroimmune factor in the CNS by a cell type that normally produces it. This approach can provide basic information about the actions of specific neuroimmune factors and can contribute to an understanding of more complex conditions when multiple neuroimmune factors are expressed. This review summarizes studies using transgenic mice that express elevated levels of IL-6, CCL2 or CXCL10 through increased astrocyte expression. The studies focus on the effects of these neuroimmune factors on synaptic function at the Schaffer collateral to CA1 pyramidal neuron synapse of the hippocampus, a brain region that plays a key role in cognitive function. |
topic |
pyramidal neurons Schaffer collaterals LTP neuroimmune alcohol field potential recordings cytokine chemokine |
url |
http://www.mdpi.com/2076-3425/6/2/19 |
work_keys_str_mv |
AT donnalgruol impactofincreasedastrocyteexpressionofil6ccl2orcxcl10intransgenicmiceonhippocampalsynapticfunction |
_version_ |
1725373946906279936 |