Comparison of the analgesic effect of intravenous paracetamol/midazolam and fentanyl in preparation
Background: Although some patients can tolerate colonoscopy procedure using fentanyl/ midazolam without any sedation and analgesic requirements but some patients may require additional sedation with benzodiazepines. We performed the present study to compare the effect of paracetamol/midazolam with f...
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doaj-c2b13b07f29147afac41dacbf73a0df92020-11-25T01:17:18ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722015-04-01628792Comparison of the analgesic effect of intravenous paracetamol/midazolam and fentanyl in preparationAbbasali Ahmadi0Parviz Amri1Javad Shokri-Shirvani2Karimollah Hajian3 Background: Although some patients can tolerate colonoscopy procedure using fentanyl/ midazolam without any sedation and analgesic requirements but some patients may require additional sedation with benzodiazepines. We performed the present study to compare the effect of paracetamol/midazolam with fentanyl/ midazolam. Methods: In a clinical trial, 96 patients aged 18 to 75 years old, who were candidate for elective colonoscopy assigned consecutively into two groups as paracetamol/midazolam and fentanyl/midazolam. The first group received 1 gr paracetamol 45 minutes before colonoscopy and 0.5 mg/kg midazolam 5 minutes before colonoscopy whereas the second group received 04- 0.5-1 mcg/kg fentanyl 3 minutes before colonoscopy and similar dose of midazolam. The two groups were compared in regard to patient intensity, discomfort, a colonoscopist and, patient satisfaction and rescue dose of propofol during colonoscopy and vital signs. Results: There was no significant difference between the two groups for patient pain score, colonoscopist satisfaction, patient satisfaction and rescue dose of propofol (P=0.817, 0.978, 0.460, and 0.104, respectively). The incidence of apnea was greater in fentanyl group (P=0.045). After adjusting for age and education, there was also no significant difference between the two groups. Conclusion: This study indicates that paracetamol can be considered as an alternative drug regimen in preparation of colonoscopy.http://caspjim.com/browse.php?a_code=A-10-237-1&slc_lang=en&sid=1Paracetamol Fentanyl Colonoscopy Analgesia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abbasali Ahmadi Parviz Amri Javad Shokri-Shirvani Karimollah Hajian |
spellingShingle |
Abbasali Ahmadi Parviz Amri Javad Shokri-Shirvani Karimollah Hajian Comparison of the analgesic effect of intravenous paracetamol/midazolam and fentanyl in preparation Caspian Journal of Internal Medicine Paracetamol Fentanyl Colonoscopy Analgesia |
author_facet |
Abbasali Ahmadi Parviz Amri Javad Shokri-Shirvani Karimollah Hajian |
author_sort |
Abbasali Ahmadi |
title |
Comparison of the analgesic effect of intravenous paracetamol/midazolam and fentanyl in preparation |
title_short |
Comparison of the analgesic effect of intravenous paracetamol/midazolam and fentanyl in preparation |
title_full |
Comparison of the analgesic effect of intravenous paracetamol/midazolam and fentanyl in preparation |
title_fullStr |
Comparison of the analgesic effect of intravenous paracetamol/midazolam and fentanyl in preparation |
title_full_unstemmed |
Comparison of the analgesic effect of intravenous paracetamol/midazolam and fentanyl in preparation |
title_sort |
comparison of the analgesic effect of intravenous paracetamol/midazolam and fentanyl in preparation |
publisher |
Babol University of Medical Sciences |
series |
Caspian Journal of Internal Medicine |
issn |
2008-6164 2008-6172 |
publishDate |
2015-04-01 |
description |
Background: Although some patients can tolerate
colonoscopy procedure using fentanyl/ midazolam without any sedation and
analgesic requirements but some patients may require additional sedation with
benzodiazepines. We performed the present study to compare the effect of
paracetamol/midazolam with fentanyl/ midazolam. Methods: In a clinical trial, 96 patients aged 18
to 75 years old, who were candidate for elective colonoscopy assigned
consecutively into two groups as paracetamol/midazolam and fentanyl/midazolam.
The first group received 1 gr paracetamol 45 minutes before colonoscopy and 0.5
mg/kg midazolam 5 minutes before colonoscopy whereas the second group received 04-
0.5-1 mcg/kg fentanyl 3 minutes before colonoscopy and similar dose of
midazolam. The two groups were compared in regard to patient intensity,
discomfort, a colonoscopist and, patient satisfaction and rescue dose
of propofol during colonoscopy and vital signs. Results: There was no significant difference
between the two groups for patient pain score, colonoscopist satisfaction,
patient satisfaction and rescue dose of propofol (P=0.817, 0.978, 0.460, and 0.104, respectively). The incidence
of apnea was greater in fentanyl group (P=0.045). After adjusting for age and
education, there was also no significant difference between the two groups. Conclusion: This study indicates that paracetamol can
be considered as an alternative drug regimen in preparation of colonoscopy. |
topic |
Paracetamol Fentanyl Colonoscopy Analgesia |
url |
http://caspjim.com/browse.php?a_code=A-10-237-1&slc_lang=en&sid=1 |
work_keys_str_mv |
AT abbasaliahmadi comparisonoftheanalgesiceffectofintravenousparacetamolmidazolamandfentanylinpreparation AT parvizamri comparisonoftheanalgesiceffectofintravenousparacetamolmidazolamandfentanylinpreparation AT javadshokrishirvani comparisonoftheanalgesiceffectofintravenousparacetamolmidazolamandfentanylinpreparation AT karimollahhajian comparisonoftheanalgesiceffectofintravenousparacetamolmidazolamandfentanylinpreparation |
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1725146715871248384 |