The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes
If left unrepaired, meiotic DSBs are toxic to mammalian cells, thus oocytes in which DSBs persist are eliminated by the DNA-damage checkpoint. Here the authors provide insights into the roles of PUMA, NOXA and BAX during DNA damage checkpoint that eliminates Dmc1 −/− and Msh5 −/− oocytes.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16441-z |
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doaj-c2bf829fec2b403580972f4e566da03c2021-05-30T11:15:49ZengNature Publishing GroupNature Communications2041-17232020-05-0111111010.1038/s41467-020-16441-zThe BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytesElias ElInati0Agata P. Zielinska1Afshan McCarthy2Nada Kubikova3Valdone Maciulyte4Shantha Mahadevaiah5Mahesh N. Sangrithi6Obah Ojarikre7Dagan Wells8Kathy K. Niakan9Melina Schuh10James M. A. Turner11Sex Chromosome Biology Laboratory, The Francis Crick InstituteMax Planck Institute for Biophysical ChemistryHuman Embryo and Stem Cell Laboratory, The Francis Crick InstituteNuffield Department of Women’s and Reproductive Health, John Radcliffe Hospital, University of OxfordSex Chromosome Biology Laboratory, The Francis Crick InstituteSex Chromosome Biology Laboratory, The Francis Crick InstituteDuke-NUS Graduate Medical SchoolSex Chromosome Biology Laboratory, The Francis Crick InstituteNuffield Department of Women’s and Reproductive Health, John Radcliffe Hospital, University of OxfordHuman Embryo and Stem Cell Laboratory, The Francis Crick InstituteMax Planck Institute for Biophysical ChemistrySex Chromosome Biology Laboratory, The Francis Crick InstituteIf left unrepaired, meiotic DSBs are toxic to mammalian cells, thus oocytes in which DSBs persist are eliminated by the DNA-damage checkpoint. Here the authors provide insights into the roles of PUMA, NOXA and BAX during DNA damage checkpoint that eliminates Dmc1 −/− and Msh5 −/− oocytes.https://doi.org/10.1038/s41467-020-16441-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Elias ElInati Agata P. Zielinska Afshan McCarthy Nada Kubikova Valdone Maciulyte Shantha Mahadevaiah Mahesh N. Sangrithi Obah Ojarikre Dagan Wells Kathy K. Niakan Melina Schuh James M. A. Turner |
| spellingShingle |
Elias ElInati Agata P. Zielinska Afshan McCarthy Nada Kubikova Valdone Maciulyte Shantha Mahadevaiah Mahesh N. Sangrithi Obah Ojarikre Dagan Wells Kathy K. Niakan Melina Schuh James M. A. Turner The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes Nature Communications |
| author_facet |
Elias ElInati Agata P. Zielinska Afshan McCarthy Nada Kubikova Valdone Maciulyte Shantha Mahadevaiah Mahesh N. Sangrithi Obah Ojarikre Dagan Wells Kathy K. Niakan Melina Schuh James M. A. Turner |
| author_sort |
Elias ElInati |
| title |
The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes |
| title_short |
The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes |
| title_full |
The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes |
| title_fullStr |
The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes |
| title_full_unstemmed |
The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes |
| title_sort |
bcl-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-05-01 |
| description |
If left unrepaired, meiotic DSBs are toxic to mammalian cells, thus oocytes in which DSBs persist are eliminated by the DNA-damage checkpoint. Here the authors provide insights into the roles of PUMA, NOXA and BAX during DNA damage checkpoint that eliminates Dmc1 −/− and Msh5 −/− oocytes. |
| url |
https://doi.org/10.1038/s41467-020-16441-z |
| work_keys_str_mv |
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