The roles of circular RNAs in human development and diseases
For many years, circular ribonucleic acids (circRNAs) have been counted as aberrant splicing by-products. Advanced bioinformatics analysis and deep sequencing techniques have allowed researchers to discover more interesting facts about circRNAs. Intriguing evidence has shed light on the functions of...
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doaj-c2c4df74dc9f4f2dbe22a83dd0a487352021-05-20T07:35:48ZengElsevierBiomedicine & Pharmacotherapy0753-33222019-03-01111198208The roles of circular RNAs in human development and diseasesEric Chun Shen Lee0Safa Abdelgadir Mohamed Elhassan1Grace Pei Ling Lim2Weng Hong Kok3Sze Wei Tan4Ee Neng Leong5Sean Hong Tan6Elaine Wan Ling Chan7Subrat Kumar Bhattamisra8Ramkumar Rajendran9Mayuren Candasamy10School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, MalaysiaSchool of Postgraduate Studies, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, MalaysiaSchool of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, MalaysiaSchool of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, MalaysiaSchool of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, MalaysiaSchool of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, MalaysiaSchool of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, MalaysiaInstitute of Research, Development and Innovation, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, MalaysiaDepartment of Life Sciences, School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, MalaysiaDepartment of Life Sciences, School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia; Corresponding authors.Department of Life Sciences, School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia; Corresponding authors.For many years, circular ribonucleic acids (circRNAs) have been counted as aberrant splicing by-products. Advanced bioinformatics analysis and deep sequencing techniques have allowed researchers to discover more interesting facts about circRNAs. Intriguing evidence has shed light on the functions of circRNAs in many tissues. Furthermore, emerging reports showed that circRNAs are found abundantly in saliva and blood samples, suggesting that circRNAs are potential clinical biomarkers for human embryonic development, diseases progression and prognosis, in addition to its role in organogenesis and pathogenesis. The implementation of circRNAs in human developmental stages and diseases would be a tremendous discovery in the science and medical field. Therefore, circRNAs have been studied for its biological function as well as its implication in various human diseases. The aim of this review is to highlight the importance of circRNAs in cardiac, respiratory, nervous, endocrine and digestive systems. In addition, the role and impact of circRNAs in, cardiogenesis, neurogenesis and cancer have been discussed.http://www.sciencedirect.com/science/article/pii/S0753332218356968Circular RNAsOrganogenesisDevelopmentBiomarkersDiseasesSystems |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eric Chun Shen Lee Safa Abdelgadir Mohamed Elhassan Grace Pei Ling Lim Weng Hong Kok Sze Wei Tan Ee Neng Leong Sean Hong Tan Elaine Wan Ling Chan Subrat Kumar Bhattamisra Ramkumar Rajendran Mayuren Candasamy |
spellingShingle |
Eric Chun Shen Lee Safa Abdelgadir Mohamed Elhassan Grace Pei Ling Lim Weng Hong Kok Sze Wei Tan Ee Neng Leong Sean Hong Tan Elaine Wan Ling Chan Subrat Kumar Bhattamisra Ramkumar Rajendran Mayuren Candasamy The roles of circular RNAs in human development and diseases Biomedicine & Pharmacotherapy Circular RNAs Organogenesis Development Biomarkers Diseases Systems |
author_facet |
Eric Chun Shen Lee Safa Abdelgadir Mohamed Elhassan Grace Pei Ling Lim Weng Hong Kok Sze Wei Tan Ee Neng Leong Sean Hong Tan Elaine Wan Ling Chan Subrat Kumar Bhattamisra Ramkumar Rajendran Mayuren Candasamy |
author_sort |
Eric Chun Shen Lee |
title |
The roles of circular RNAs in human development and diseases |
title_short |
The roles of circular RNAs in human development and diseases |
title_full |
The roles of circular RNAs in human development and diseases |
title_fullStr |
The roles of circular RNAs in human development and diseases |
title_full_unstemmed |
The roles of circular RNAs in human development and diseases |
title_sort |
roles of circular rnas in human development and diseases |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2019-03-01 |
description |
For many years, circular ribonucleic acids (circRNAs) have been counted as aberrant splicing by-products. Advanced bioinformatics analysis and deep sequencing techniques have allowed researchers to discover more interesting facts about circRNAs. Intriguing evidence has shed light on the functions of circRNAs in many tissues. Furthermore, emerging reports showed that circRNAs are found abundantly in saliva and blood samples, suggesting that circRNAs are potential clinical biomarkers for human embryonic development, diseases progression and prognosis, in addition to its role in organogenesis and pathogenesis. The implementation of circRNAs in human developmental stages and diseases would be a tremendous discovery in the science and medical field. Therefore, circRNAs have been studied for its biological function as well as its implication in various human diseases. The aim of this review is to highlight the importance of circRNAs in cardiac, respiratory, nervous, endocrine and digestive systems. In addition, the role and impact of circRNAs in, cardiogenesis, neurogenesis and cancer have been discussed. |
topic |
Circular RNAs Organogenesis Development Biomarkers Diseases Systems |
url |
http://www.sciencedirect.com/science/article/pii/S0753332218356968 |
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