Effect of combination antiretroviral therapy on the frequency of oral candidiasis in HIV/AIDS patient

• Main Author: Sayuti Hasibuan
• Format: Article
• Language: English
• Published: Universitas Airlangga 2007-03-01
• Series: Dental Journal: Majalah Kedokteran Gigi
• Subjects: HIV/AIDS; Oral candidiasis; Antiretroviral; HAART
• Online Access: http://e-journal.unair.ac.id/index.php/MKG/article/view/1066
• ISSN: 1978-3728; 2442-9740

<span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>Oral candidiasis is one of the most common opportunistic infections in HIV/AIDS patients. It serves as important markers of HIV </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>infection, viral load, and CD4 cells count in the blood and predict disease progression to AIDS. The development of oral candidiasis </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>in HIV/AIDS patients associated by imbalances between Candida and impaired host immune defenses that caused by decreased of </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>CD4 cell counts and the increased of plasma HIV-viral load. Since the introduction of antiretroviral therapy combination, commonly </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>known as Highly Active Antiretroviral Therapy (HAART), it has been observed that certain oral lesions, such as oral candidiasis as </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>declined. The aim of this paper is to review the mechanism of combination antiretroviral therapy influenced the frequency of oral </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>candidiasis in HIV/AIDS patient. We conclude that combination antiretroviral therapy generally reduced the frequency and severity </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>of oral candidiasis in HIV/AIDS patient.</em></span></span></span></span></span></span></span><br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;" /></span>