Measuring Animal Age with DNA Methylation: From Humans to Wild Animals
DNA methylation (DNAm) is a key mechanism for regulating gene expression in animals and levels are known to change with age. Recent studies have used DNAm changes as a biomarker to estimate chronological age in humans and these techniques are now also being applied to domestic and wild animals. Anim...
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doaj-c2d98ae03f264bf4bfc1c9d0551e49072020-11-24T23:21:13ZengFrontiers Media S.A.Frontiers in Genetics1664-80212017-08-01810.3389/fgene.2017.00106290930Measuring Animal Age with DNA Methylation: From Humans to Wild AnimalsRicardo De Paoli-Iseppi0Ricardo De Paoli-Iseppi1Bruce E. Deagle2Clive R. McMahon3Mark A. Hindell4Joanne L. Dickinson5Simon N. Jarman6Simon N. Jarman7Institute for Marine and Antarctic Studies, University of TasmaniaHobart, TAS, AustraliaAustralian Antarctic DivisionHobart, TAS, AustraliaAustralian Antarctic DivisionHobart, TAS, AustraliaSydney Institute of Marine ScienceSydney, NSW, AustraliaInstitute for Marine and Antarctic Studies, University of TasmaniaHobart, TAS, AustraliaCancer, Genetics and Immunology Group, Menzies Institute for Medical ResearchHobart, TAS, AustraliaTrace and Environmental DNA Laboratory, Department of Environment and Agriculture, Curtin UniversityPerth, WA, AustraliaCSIRO Indian Ocean Marine Research Centre, University of Western AustraliaPerth, WA, AustraliaDNA methylation (DNAm) is a key mechanism for regulating gene expression in animals and levels are known to change with age. Recent studies have used DNAm changes as a biomarker to estimate chronological age in humans and these techniques are now also being applied to domestic and wild animals. Animal age is widely used to track ongoing changes in ecosystems, however chronological age information is often unavailable for wild animals. An ability to estimate age would lead to improved monitoring of (i) population trends and status and (ii) demographic properties such as age structure and reproductive performance. Recent studies have revealed new examples of DNAm age association in several new species increasing the potential for developing DNAm age biomarkers for a broad range of wild animals. Emerging technologies for measuring DNAm will also enhance our ability to study age-related DNAm changes and to develop new molecular age biomarkers.http://journal.frontiersin.org/article/10.3389/fgene.2017.00106/fullepigeneticsageingmethylationwild animalsconservationecology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ricardo De Paoli-Iseppi Ricardo De Paoli-Iseppi Bruce E. Deagle Clive R. McMahon Mark A. Hindell Joanne L. Dickinson Simon N. Jarman Simon N. Jarman |
spellingShingle |
Ricardo De Paoli-Iseppi Ricardo De Paoli-Iseppi Bruce E. Deagle Clive R. McMahon Mark A. Hindell Joanne L. Dickinson Simon N. Jarman Simon N. Jarman Measuring Animal Age with DNA Methylation: From Humans to Wild Animals Frontiers in Genetics epigenetics ageing methylation wild animals conservation ecology |
author_facet |
Ricardo De Paoli-Iseppi Ricardo De Paoli-Iseppi Bruce E. Deagle Clive R. McMahon Mark A. Hindell Joanne L. Dickinson Simon N. Jarman Simon N. Jarman |
author_sort |
Ricardo De Paoli-Iseppi |
title |
Measuring Animal Age with DNA Methylation: From Humans to Wild Animals |
title_short |
Measuring Animal Age with DNA Methylation: From Humans to Wild Animals |
title_full |
Measuring Animal Age with DNA Methylation: From Humans to Wild Animals |
title_fullStr |
Measuring Animal Age with DNA Methylation: From Humans to Wild Animals |
title_full_unstemmed |
Measuring Animal Age with DNA Methylation: From Humans to Wild Animals |
title_sort |
measuring animal age with dna methylation: from humans to wild animals |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2017-08-01 |
description |
DNA methylation (DNAm) is a key mechanism for regulating gene expression in animals and levels are known to change with age. Recent studies have used DNAm changes as a biomarker to estimate chronological age in humans and these techniques are now also being applied to domestic and wild animals. Animal age is widely used to track ongoing changes in ecosystems, however chronological age information is often unavailable for wild animals. An ability to estimate age would lead to improved monitoring of (i) population trends and status and (ii) demographic properties such as age structure and reproductive performance. Recent studies have revealed new examples of DNAm age association in several new species increasing the potential for developing DNAm age biomarkers for a broad range of wild animals. Emerging technologies for measuring DNAm will also enhance our ability to study age-related DNAm changes and to develop new molecular age biomarkers. |
topic |
epigenetics ageing methylation wild animals conservation ecology |
url |
http://journal.frontiersin.org/article/10.3389/fgene.2017.00106/full |
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