First Indian report of IncX3 plasmid carrying blaNDM-7 in Escherichia coli from bloodstream infection: potential for rapid dissemination

First Indian report of IncX3 plasmid carrying blaNDM-7 in Escherichia coli from bloodstream infection: potential for rapid dissemination

Enterobacteriaceae with blaNDM-7 is only infrequently observed. Self-transmissible plasmids carrying the blaNDM gene increase the dissemination of carbapenem resistance in developing countries. This study investigates the whole genome sequence of a blaNDM-7-positive Escherichia coli. The isolate was...

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Bibliographic Details
Main Authors: N.K. Devanga Ragupathi, D.P. Muthuirulandi Sethuvel, R. Gajendiran, J.L.K. Daniel, K. Walia, B. Veeraraghavan
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:New Microbes and New Infections
Subjects:
blaNDM-7
carbapenem resistance
IncX3
ST167 Escherichia coli
whole genome sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2052297517300124
Description
Summary:Enterobacteriaceae with blaNDM-7 is only infrequently observed. Self-transmissible plasmids carrying the blaNDM gene increase the dissemination of carbapenem resistance in developing countries. This study investigates the whole genome sequence of a blaNDM-7-positive Escherichia coli. The isolate was an extended-spectrum β-lactamase producer by combined disc diffusion test and carbapenemase producer by CarbaNP method. Sequencing results revealed the isolate as E. coli ST-167 with IncX3 plasmid carrying blaNDM-7 in addition to blaTEM-1 and blaCMY-42 genes. The identification of IncX3-blaNDM-7 combination is the first report in India where blaNDM-7 is known to cause higher resistance to carbapenems compared to its variants.
ISSN:2052-2975

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