ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS
Abstract. Autoimmune thyroiditis (Hashimoto’s thyroiditis, HT) still represents an unresolved problem of modern endocrinology, since its etiology and pathogenesis are yet unclear. Cytokines play an important role in the regulation of immune and inflammatory response, therefore, some gene v...
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doaj-c2e3d72724624a88b22751fd426cca382021-07-29T09:02:27ZrusSPb RAACIMedicinskaâ Immunologiâ1563-06252313-741X2014-07-0113660360810.15789/1563-0625-2011-6-603-608598ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITISE. M. Biktagirova0L. I. Sattarova1G. R. Vagapova2O. A. Kravtsova3Казанский (Приволжский) федеральный университет, г. КазаньГосударственное учреждение Межрегиональный клинико-диагностический центр (ГУ МКДЦ), г.КазаньГосударственное образовательное учреждение дополнительного профессионального обучения «Казанская государственная медицинская академия Росздрава», г. КазаньКазанский (Приволжский) федеральный университет, г. КазаньAbstract. Autoimmune thyroiditis (Hashimoto’s thyroiditis, HT) still represents an unresolved problem of modern endocrinology, since its etiology and pathogenesis are yet unclear. Cytokines play an important role in the regulation of immune and inflammatory response, therefore, some gene variants encoding them, are considered as potential risk risk factors for autoimmune thyroid diseases. We have genotyped 298 women from the Republic of Tatarstan (RT, control group, 137 persons; HT patients, 161) for the following gene polymorphisms: interleukin-1 beta (IL-1β) +3953 C/T (rs 1143634); interleukin 4 (IL-4) -590C/T (rs 2243250), and interleukin 6 (IL-6) -174C/G (rs 1800795), using allele-specific PCR. The results showed a significantly increased frequencies of C allele (P = 0.0003) and CT genotype (P = 0.048, OR = 6.05, 95%CI 2.59-2.97) of +3953 C/T of IL-1β in patients with Hashimoto's thyroiditis, as compared with control group. The latter group showed higher prevalence of T allele (P = 0.0003) and TT genotype (P = 4.95 Ч 6.10; OR = 0.15, 95%CI 0.06-0.38). The 590C/T and -174C/G polymorphic variants in, resp., IL-4 and IL-6 genes are not associated with increased risk of this disease among women from RT. (Med. Immunol., 2011, vol. 13, N 6, pp 603-608)https://www.mimmun.ru/mimmun/article/view/601autoimmune thyroiditisgene polymorphisminterleukin 1βinterleukin 4interleukin 6 |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
E. M. Biktagirova L. I. Sattarova G. R. Vagapova O. A. Kravtsova |
spellingShingle |
E. M. Biktagirova L. I. Sattarova G. R. Vagapova O. A. Kravtsova ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS Medicinskaâ Immunologiâ autoimmune thyroiditis gene polymorphism interleukin 1β interleukin 4 interleukin 6 |
author_facet |
E. M. Biktagirova L. I. Sattarova G. R. Vagapova O. A. Kravtsova |
author_sort |
E. M. Biktagirova |
title |
ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS |
title_short |
ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS |
title_full |
ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS |
title_fullStr |
ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS |
title_full_unstemmed |
ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS |
title_sort |
association of il-1β, il-4 and il-6 genes polymorphisms with genetic predisposition for autoimmune thyroiditis |
publisher |
SPb RAACI |
series |
Medicinskaâ Immunologiâ |
issn |
1563-0625 2313-741X |
publishDate |
2014-07-01 |
description |
Abstract. Autoimmune thyroiditis (Hashimoto’s thyroiditis, HT) still represents an unresolved problem of modern endocrinology, since its etiology and pathogenesis are yet unclear. Cytokines play an important role in the regulation of immune and inflammatory response, therefore, some gene variants encoding them, are considered as potential risk risk factors for autoimmune thyroid diseases. We have genotyped 298 women from the Republic of Tatarstan (RT, control group, 137 persons; HT patients, 161) for the following gene polymorphisms: interleukin-1 beta (IL-1β) +3953 C/T (rs 1143634); interleukin 4 (IL-4) -590C/T (rs 2243250), and interleukin 6 (IL-6) -174C/G (rs 1800795), using allele-specific PCR. The results showed a significantly increased frequencies of C allele (P = 0.0003) and CT genotype (P = 0.048, OR = 6.05, 95%CI 2.59-2.97) of +3953 C/T of IL-1β in patients with Hashimoto's thyroiditis, as compared with control group. The latter group showed higher prevalence of T allele (P = 0.0003) and TT genotype (P = 4.95 Ч 6.10; OR = 0.15, 95%CI 0.06-0.38). The 590C/T and -174C/G polymorphic variants in, resp., IL-4 and IL-6 genes are not associated with increased risk of this disease among women from RT. (Med. Immunol., 2011, vol. 13, N 6, pp 603-608) |
topic |
autoimmune thyroiditis gene polymorphism interleukin 1β interleukin 4 interleukin 6 |
url |
https://www.mimmun.ru/mimmun/article/view/601 |
work_keys_str_mv |
AT embiktagirova associationofil1bil4andil6genespolymorphismswithgeneticpredispositionforautoimmunethyroiditis AT lisattarova associationofil1bil4andil6genespolymorphismswithgeneticpredispositionforautoimmunethyroiditis AT grvagapova associationofil1bil4andil6genespolymorphismswithgeneticpredispositionforautoimmunethyroiditis AT oakravtsova associationofil1bil4andil6genespolymorphismswithgeneticpredispositionforautoimmunethyroiditis |
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1721249988600659968 |