Effects of obesity on liver cytochromes P450 in various animal models
The prevalence of obesity and other obesity-related diseases is increasing worldwide. Obesity is a disease characterized by increased body weight, or a condition resulting from excessive accumulation of body fat. Due to increased body fat deposits, obesity has also been associated with increased mor...
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2017-06-01
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doaj-c2e5d58dacc844698e8053b275db2bfc2020-11-25T01:25:45ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212017-06-01161214415110.5507/bp.2017.026bio-201702-0004Effects of obesity on liver cytochromes P450 in various animal modelsVeronika Tomankova0Pavel Anzenbacher1Eva Anzenbacherova2Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicDepartment of Pharmacology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicDepartment of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicThe prevalence of obesity and other obesity-related diseases is increasing worldwide. Obesity is a disease characterized by increased body weight, or a condition resulting from excessive accumulation of body fat. Due to increased body fat deposits, obesity has also been associated with increased mortality resulting from higher incidence rates of hypertension, diabetes, or various types of cancer, such as breast, colorectal, cervical and prostate cancer. Physiological changes associated with obesity are likely to result in altered drug biotransformation. The main enzymes enabling the oxidative biotransformation of most drugs are cytochromes P450 (CYPs). The review summarizes how pathophysiological factors, especially obesity, affect properties (e.g. enzyme activity, protein expression, gene expression) of CYP enzymes in various experimental models of human obesity. Results reported by various authors suggest that obesity is associated with a decrease of CYP activities (except for the CYP2C and CYP2E1 enzymes). The only exception is mouse obesity induced by monosodium glutamate (administered to newborn mice) as it usually leads to increased CYP expression. Selecting an animal model that is as close as possible to the properties of human obesity is of paramount importance.https://biomed.papers.upol.cz/artkey/bio-201702-0004_Effects_of_obesity_on_liver_cytochromes_P450_in_various_animal_models.phpobesityanimal modelcytochrome p450drug metabolismenzyme activityprotein levelmrna level |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Veronika Tomankova Pavel Anzenbacher Eva Anzenbacherova |
spellingShingle |
Veronika Tomankova Pavel Anzenbacher Eva Anzenbacherova Effects of obesity on liver cytochromes P450 in various animal models Biomedical Papers obesity animal model cytochrome p450 drug metabolism enzyme activity protein level mrna level |
author_facet |
Veronika Tomankova Pavel Anzenbacher Eva Anzenbacherova |
author_sort |
Veronika Tomankova |
title |
Effects of obesity on liver cytochromes P450 in various animal models |
title_short |
Effects of obesity on liver cytochromes P450 in various animal models |
title_full |
Effects of obesity on liver cytochromes P450 in various animal models |
title_fullStr |
Effects of obesity on liver cytochromes P450 in various animal models |
title_full_unstemmed |
Effects of obesity on liver cytochromes P450 in various animal models |
title_sort |
effects of obesity on liver cytochromes p450 in various animal models |
publisher |
Palacký University Olomouc, Faculty of Medicine and Dentistry |
series |
Biomedical Papers |
issn |
1213-8118 1804-7521 |
publishDate |
2017-06-01 |
description |
The prevalence of obesity and other obesity-related diseases is increasing worldwide. Obesity is a disease characterized by increased body weight, or a condition resulting from excessive accumulation of body fat. Due to increased body fat deposits, obesity has also been associated with increased mortality resulting from higher incidence rates of hypertension, diabetes, or various types of cancer, such as breast, colorectal, cervical and prostate cancer. Physiological changes associated with obesity are likely to result in altered drug biotransformation. The main enzymes enabling the oxidative biotransformation of most drugs are cytochromes P450 (CYPs). The review summarizes how pathophysiological factors, especially obesity, affect properties (e.g. enzyme activity, protein expression, gene expression) of CYP enzymes in various experimental models of human obesity. Results reported by various authors suggest that obesity is associated with a decrease of CYP activities (except for the CYP2C and CYP2E1 enzymes). The only exception is mouse obesity induced by monosodium glutamate (administered to newborn mice) as it usually leads to increased CYP expression. Selecting an animal model that is as close as possible to the properties of human obesity is of paramount importance. |
topic |
obesity animal model cytochrome p450 drug metabolism enzyme activity protein level mrna level |
url |
https://biomed.papers.upol.cz/artkey/bio-201702-0004_Effects_of_obesity_on_liver_cytochromes_P450_in_various_animal_models.php |
work_keys_str_mv |
AT veronikatomankova effectsofobesityonlivercytochromesp450invariousanimalmodels AT pavelanzenbacher effectsofobesityonlivercytochromesp450invariousanimalmodels AT evaanzenbacherova effectsofobesityonlivercytochromesp450invariousanimalmodels |
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1725112077053329408 |