LMO7 deficiency reveals the significance of the cuticular plate for hearing function
In contrast to the extensively studied mechanosensory hair bundle, the cuticular plate is not as well understood. In this study, authors describe the discovery of a hair cell protein called LIM only protein 7, which is localized in the cuticular plate and the cell junction and may play a role in age...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09074-4 |
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doaj-c2ec714b45bc41bf96953f0212beec8a2021-05-11T11:34:03ZengNature Publishing GroupNature Communications2041-17232019-03-0110111510.1038/s41467-019-09074-4LMO7 deficiency reveals the significance of the cuticular plate for hearing functionTing-Ting Du0James B. Dewey1Elizabeth L. Wagner2Runjia Cui3Jinho Heo4Jeong-Jin Park5Shimon P. Francis6Edward Perez-Reyes7Stacey J. Guillot8Nicholas E. Sherman9Wenhao Xu10John S Oghalai11Bechara Kachar12Jung-Bum Shin13Department of Neuroscience, University of VirginiaCaruso Department of Otolaryngology-Head and Neck Surgery, University of Southern CaliforniaDepartment of Neuroscience, University of VirginiaNational Institute for Deafness and Communications Disorders, National Institute of HealthCenter for Cell Signaling and Department of Microbiology, Immunology and Cancer Biology, University of VirginiaBiomolecular Analysis Facility, University of VirginiaDepartment of Neuroscience, University of VirginiaDepartment of Pharmacology, University of VirginiaAdvanced Microscopy core, University of VirginiaBiomolecular Analysis Facility, University of VirginiaGenetically Engineered Murine Model (GEMM) core, University of VirginiaCaruso Department of Otolaryngology-Head and Neck Surgery, University of Southern CaliforniaNational Institute for Deafness and Communications Disorders, National Institute of HealthDepartment of Neuroscience, University of VirginiaIn contrast to the extensively studied mechanosensory hair bundle, the cuticular plate is not as well understood. In this study, authors describe the discovery of a hair cell protein called LIM only protein 7, which is localized in the cuticular plate and the cell junction and may play a role in age-related deafness.https://doi.org/10.1038/s41467-019-09074-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ting-Ting Du James B. Dewey Elizabeth L. Wagner Runjia Cui Jinho Heo Jeong-Jin Park Shimon P. Francis Edward Perez-Reyes Stacey J. Guillot Nicholas E. Sherman Wenhao Xu John S Oghalai Bechara Kachar Jung-Bum Shin |
| spellingShingle |
Ting-Ting Du James B. Dewey Elizabeth L. Wagner Runjia Cui Jinho Heo Jeong-Jin Park Shimon P. Francis Edward Perez-Reyes Stacey J. Guillot Nicholas E. Sherman Wenhao Xu John S Oghalai Bechara Kachar Jung-Bum Shin LMO7 deficiency reveals the significance of the cuticular plate for hearing function Nature Communications |
| author_facet |
Ting-Ting Du James B. Dewey Elizabeth L. Wagner Runjia Cui Jinho Heo Jeong-Jin Park Shimon P. Francis Edward Perez-Reyes Stacey J. Guillot Nicholas E. Sherman Wenhao Xu John S Oghalai Bechara Kachar Jung-Bum Shin |
| author_sort |
Ting-Ting Du |
| title |
LMO7 deficiency reveals the significance of the cuticular plate for hearing function |
| title_short |
LMO7 deficiency reveals the significance of the cuticular plate for hearing function |
| title_full |
LMO7 deficiency reveals the significance of the cuticular plate for hearing function |
| title_fullStr |
LMO7 deficiency reveals the significance of the cuticular plate for hearing function |
| title_full_unstemmed |
LMO7 deficiency reveals the significance of the cuticular plate for hearing function |
| title_sort |
lmo7 deficiency reveals the significance of the cuticular plate for hearing function |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-03-01 |
| description |
In contrast to the extensively studied mechanosensory hair bundle, the cuticular plate is not as well understood. In this study, authors describe the discovery of a hair cell protein called LIM only protein 7, which is localized in the cuticular plate and the cell junction and may play a role in age-related deafness. |
| url |
https://doi.org/10.1038/s41467-019-09074-4 |
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