Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides

Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides

2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for theirantitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM againstproliferation of the human promyelotic leukemia (HL60) cell lin...

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Main Authors: Hussein F.. Zohdi, Ayman M. Saleh, Ibrahim M. Abdou
Format: Article
Language:English
Published: MDPI AG 2004-02-01
Series:Molecules
Subjects:
Trifluoromethylpyrazole
glucopyranose
antitumor agents.
Online Access:http://www.mdpi.com/1420-3049/9/3/109/
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spelling doaj-c2eccd7eec504f5683897bf869d72fc92020-11-24T23:18:10ZengMDPI AGMolecules1420-30492004-02-019310911610.3390/90300109Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one NucleosidesHussein F.. ZohdiAyman M. SalehIbrahim M. Abdou2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for theirantitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM againstproliferation of the human promyelotic leukemia (HL60) cell line.http://www.mdpi.com/1420-3049/9/3/109/Trifluoromethylpyrazoleglucopyranoseantitumor agents.
collection DOAJ
language English
format Article
sources DOAJ
author Hussein F.. Zohdi
Ayman M. Saleh
Ibrahim M. Abdou
spellingShingle Hussein F.. Zohdi
Ayman M. Saleh
Ibrahim M. Abdou
Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides
Molecules
Trifluoromethylpyrazole
glucopyranose
antitumor agents.
author_facet Hussein F.. Zohdi
Ayman M. Saleh
Ibrahim M. Abdou
author_sort Hussein F.. Zohdi
title Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides
title_short Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides
title_full Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides
title_fullStr Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides
title_full_unstemmed Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides
title_sort synthesis and antitumor activity of 5-trifluoromethyl-2,4- dihydropyrazol-3-one nucleosides
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2004-02-01
description 2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for theirantitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM againstproliferation of the human promyelotic leukemia (HL60) cell line.
topic Trifluoromethylpyrazole
glucopyranose
antitumor agents.
url http://www.mdpi.com/1420-3049/9/3/109/
work_keys_str_mv AT husseinfzohdi synthesisandantitumoractivityof5trifluoromethyl24dihydropyrazol3onenucleosides
AT aymanmsaleh synthesisandantitumoractivityof5trifluoromethyl24dihydropyrazol3onenucleosides
AT ibrahimmabdou synthesisandantitumoractivityof5trifluoromethyl24dihydropyrazol3onenucleosides
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