Secoisolariciresinol Diglucoside of Flaxseed and Its Metabolites: Biosynthesis and Potential for Nutraceuticals
Secoisolariciresinol diglucoside (SDG), found mainly in flaxseed, is one of the essential lignans. SDG, as well as the beneficial fatty acid composition and high fiber content, has made flaxseed an important source of functional food or nutraceutical ingredients. Various studies have shown that SDG...
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doaj-c2edd9f702714ad28049013f20c2034a2020-11-25T01:40:05ZengFrontiers Media S.A.Frontiers in Genetics1664-80212018-12-01910.3389/fgene.2018.00641422283Secoisolariciresinol Diglucoside of Flaxseed and Its Metabolites: Biosynthesis and Potential for NutraceuticalsParfait Kezimana0Parfait Kezimana1Alexey A. Dmitriev2Anna V. Kudryavtseva3Elena V. Romanova4Nataliya V. Melnikova5Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, RussiaDepartment of Agrobiotechnology, Peoples’ Friendship University of Russia (RUDN University), Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, RussiaDepartment of Agrobiotechnology, Peoples’ Friendship University of Russia (RUDN University), Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, RussiaSecoisolariciresinol diglucoside (SDG), found mainly in flaxseed, is one of the essential lignans. SDG, as well as the beneficial fatty acid composition and high fiber content, has made flaxseed an important source of functional food or nutraceutical ingredients. Various studies have shown that SDG offers several health benefits, including protective effects against cardiovascular diseases, diabetes, cancer, and mental stress. These health benefits have been attributed to the antioxidant properties of SDG. Additionally, SDG metabolites, namely mammalian lignans, enterodiol and enterolactone, have shown promising effects against cancer. Therefore, understanding the biosynthetic pathway of SDG and its molecular mechanisms is a key to enable the production of new flaxseed cultivars rich in nutraceutical content. The present review highlights studies on the different health benefits of SDG, as well as lignan biosynthesis in flaxseed and genes involved in the biosynthetic pathway. Since SDG, the predominant lignan in flaxseed, is a glycosylated lignan, we also focus on studies investigating the genes involved in secoisolariciresinol glycosylation. These genes can be used to produce new cultivars with a novel level of glycosylation or lignan composition to maximize the yields of lignans with a therapeutic or protective potential.https://www.frontiersin.org/article/10.3389/fgene.2018.00641/fulllignansflaxseedglycosyltransferasesLinumpinoresinol-lariciresinol reductasesecoisolariciresinol diglucoside |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Parfait Kezimana Parfait Kezimana Alexey A. Dmitriev Anna V. Kudryavtseva Elena V. Romanova Nataliya V. Melnikova |
spellingShingle |
Parfait Kezimana Parfait Kezimana Alexey A. Dmitriev Anna V. Kudryavtseva Elena V. Romanova Nataliya V. Melnikova Secoisolariciresinol Diglucoside of Flaxseed and Its Metabolites: Biosynthesis and Potential for Nutraceuticals Frontiers in Genetics lignans flaxseed glycosyltransferases Linum pinoresinol-lariciresinol reductase secoisolariciresinol diglucoside |
author_facet |
Parfait Kezimana Parfait Kezimana Alexey A. Dmitriev Anna V. Kudryavtseva Elena V. Romanova Nataliya V. Melnikova |
author_sort |
Parfait Kezimana |
title |
Secoisolariciresinol Diglucoside of Flaxseed and Its Metabolites: Biosynthesis and Potential for Nutraceuticals |
title_short |
Secoisolariciresinol Diglucoside of Flaxseed and Its Metabolites: Biosynthesis and Potential for Nutraceuticals |
title_full |
Secoisolariciresinol Diglucoside of Flaxseed and Its Metabolites: Biosynthesis and Potential for Nutraceuticals |
title_fullStr |
Secoisolariciresinol Diglucoside of Flaxseed and Its Metabolites: Biosynthesis and Potential for Nutraceuticals |
title_full_unstemmed |
Secoisolariciresinol Diglucoside of Flaxseed and Its Metabolites: Biosynthesis and Potential for Nutraceuticals |
title_sort |
secoisolariciresinol diglucoside of flaxseed and its metabolites: biosynthesis and potential for nutraceuticals |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2018-12-01 |
description |
Secoisolariciresinol diglucoside (SDG), found mainly in flaxseed, is one of the essential lignans. SDG, as well as the beneficial fatty acid composition and high fiber content, has made flaxseed an important source of functional food or nutraceutical ingredients. Various studies have shown that SDG offers several health benefits, including protective effects against cardiovascular diseases, diabetes, cancer, and mental stress. These health benefits have been attributed to the antioxidant properties of SDG. Additionally, SDG metabolites, namely mammalian lignans, enterodiol and enterolactone, have shown promising effects against cancer. Therefore, understanding the biosynthetic pathway of SDG and its molecular mechanisms is a key to enable the production of new flaxseed cultivars rich in nutraceutical content. The present review highlights studies on the different health benefits of SDG, as well as lignan biosynthesis in flaxseed and genes involved in the biosynthetic pathway. Since SDG, the predominant lignan in flaxseed, is a glycosylated lignan, we also focus on studies investigating the genes involved in secoisolariciresinol glycosylation. These genes can be used to produce new cultivars with a novel level of glycosylation or lignan composition to maximize the yields of lignans with a therapeutic or protective potential. |
topic |
lignans flaxseed glycosyltransferases Linum pinoresinol-lariciresinol reductase secoisolariciresinol diglucoside |
url |
https://www.frontiersin.org/article/10.3389/fgene.2018.00641/full |
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