LETM1 Knockdown Promotes Autophagy and Apoptosis Through AMP-Activated Protein Kinase Phosphorylation-Mediated Beclin-1/Bcl-2 Complex Dissociation in Hepatocellular Carcinoma

LETM1 Knockdown Promotes Autophagy and Apoptosis Through AMP-Activated Protein Kinase Phosphorylation-Mediated Beclin-1/Bcl-2 Complex Dissociation in Hepatocellular Carcinoma

Leucine zipper/EF hand-containing transmembrane-1 (LETM1) is an inner mitochondrial membrane protein that has been reported to be involved in many primary tumors and may regulate many biological processes. However, the biological role and molecular mechanism of LETM1 in the progression of hepatocell...

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Bibliographic Details
Main Authors: Baoyong Zhou, Changhong Yang, Xiong Yan, Zhengrong Shi, Heng Xiao, Xufu Wei, Ning Jiang, Zhongjun Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma
LETM1
apoptosis
autophagy
AMP-activated protein kinase (AMPK)
beclin-1/Bcl-2 complex
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.606790/full

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