Production of monoclonal antibody to MSP-2 and evaluation of different domains of the molecule
Background: Plasmodiom falciparum MSP-2 is taken into accout as one of the candidates of vaccine agaist malaria and various studies indicated immunizing effect of different domains of the molecule. Monoclonal antibody against MSP-2 is a confident and definite method to confirm this Immunization. Mat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Lorestan University of Medical Science
2009-04-01
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| Series: | Yafteh |
| Subjects: | |
| Online Access: | http://yafte.lums.ac.ir/browse.php?a_code=A-10-1-111&slc_lang=en&sid=1 |
| Summary: | Background: Plasmodiom falciparum MSP-2 is taken into accout as one of the candidates of vaccine agaist malaria and various studies indicated immunizing effect of different domains of the molecule. Monoclonal antibody against MSP-2 is a confident and definite method to confirm this Immunization.
Materials and Methods: P. falciparum Parasite was Prepared in a Culture in CludingRPMI1640 and Schizontantingens extracted and injected into the mice. Then B Lyphocytes of immunized mice were extracted from their spleen and the fusion was Performed using NS-1 and monoclonal antibody to MSP-2 was Produced.
Results: Anumber of monoclonal antibody to MSP-2 weres Produced which confirmed efficiency and Immunizing effects of various domains of MSP-2 molecule. |
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| ISSN: | 1563-0773 |