Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects
Planar cell polarity (PCP) is controlled by a conserved pathway that regulates directional cell behavior. Here, we show that mutant mice harboring a newly described mutation termed Beetlejuice (Bj) in Prickle1 (Pk1), a PCP component, exhibit developmental phenotypes involving cell polarity defects,...
Main Authors: | Brian C. Gibbs, Rama Rao Damerla, Eszter K. Vladar, Bishwanath Chatterjee, Yong Wan, Xiaoqin Liu, Cheng Cui, George C. Gabriel, Maliha Zahid, Hisato Yagi, Heather L. Szabo-Rogers, Kaye L. Suyama, Jeffrey D. Axelrod, Cecilia W. Lo |
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Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2016-03-01
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Series: | Biology Open |
Subjects: | |
Online Access: | http://bio.biologists.org/content/5/3/323 |
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