Irreversible electroporation of locally advanced unresectable pancreatic cancer

• Main Authors: Yu I Patyutko, A N Polyakov, N E Kudashkin, D V Podluzhnyi, O V Chistyakova
• Format: Article
• Language: Russian
• Published: IP Habib O.N. 2017-09-01
• Series: Современная онкология
• Subjects: locally advancesd pancreatic cancer; irreversible electroporation
• Online Access: https://modernonco.orscience.ru/1815-1434/article/viewFile/27156/pdf

Aim: to improve the results of treatment of patients with locally advancesd pancreatic cancer. Matherials and methods. From February 2015 till June 2017 there was performed 6 irreversible electroporations of unresectable pancreatic cancers, one of which was combined with palliative gastropanreatoduodenectomy. The median tumor size was 41.7 mm (range from 22 to 65 mm). The median quantity of treated areas was 2.3 (1-5). Perioperative treatment was routinely used. Results. Two patients had complications. One died on the 21st day from the pancreonecrosis with parapancreatic abscesses. Autopsy showed there was no evidence of tumor cells in the site of electroporation performed. In the other case there were revealed several foci of destruction around the area of electroporation which required sanation under the endoscopic US-guidance. In different periods of observation (1-, 3-, 4 and 12 month) four patients were alive without sign of progression. One patient died in 13 month from progression. Conclusion: irreversible electroporation - is one of the effective local treatment methods for the patiemts with unresectable nonmetastatic pancreatic cancer. To increase treatment results it is recommended to combine electroporation with chemoor radiotherapy.