The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections

The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections

The discovery of antibiotics has revolutionized the medicine and treatment of microbial infections. However, the current scenario has highlighted the difficulties in marketing new antibiotics and an exponential increase in the appearance of resistant strains. On the other hand, research in the field...

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Main Authors: Floriana Cappiello, Maria Rosa Loffredo, Cristina Del Plato, Silvia Cammarone, Bruno Casciaro, Deborah Quaglio, Maria Luisa Mangoni, Bruno Botta, Francesca Ghirga
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Antibiotics
Subjects:
antibiotic resistance
plant secondary metabolites
plant-derived natural products
terpenes
diterpenes
triterpenes
Online Access:https://www.mdpi.com/2079-6382/9/6/325
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spelling doaj-c30c823f93194d5992c5d4fd2124d4fa2020-11-25T03:29:36ZengMDPI AGAntibiotics2079-63822020-06-01932532510.3390/antibiotics9060325The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant InfectionsFloriana Cappiello0Maria Rosa Loffredo1Cristina Del Plato2Silvia Cammarone3Bruno Casciaro4Deborah Quaglio5Maria Luisa Mangoni6Bruno Botta7Francesca Ghirga8Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyLaboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Chemistry and Technology of Drugs, “Department of Excellence 2018−2022”, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Chemistry and Technology of Drugs, “Department of Excellence 2018−2022”, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyCenter For Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, ItalyDepartment of Chemistry and Technology of Drugs, “Department of Excellence 2018−2022”, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyLaboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Chemistry and Technology of Drugs, “Department of Excellence 2018−2022”, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyCenter For Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, ItalyThe discovery of antibiotics has revolutionized the medicine and treatment of microbial infections. However, the current scenario has highlighted the difficulties in marketing new antibiotics and an exponential increase in the appearance of resistant strains. On the other hand, research in the field of drug-discovery has revaluated the potential of natural products as a unique source for new biologically active molecules and scaffolds for the medicinal chemistry. In this review, we first contextualized the worldwide problem of antibiotic resistance and the importance that natural products of plant origin acquire as a source of new lead compounds. We then focused on terpenes and their potential development as antimicrobials, highlighting those studies that showed an activity against conventional antibiotic-resistant strains.https://www.mdpi.com/2079-6382/9/6/325antibiotic resistanceplant secondary metabolitesplant-derived natural productsterpenesditerpenestriterpenes
collection DOAJ
language English
format Article
sources DOAJ
author Floriana Cappiello
Maria Rosa Loffredo
Cristina Del Plato
Silvia Cammarone
Bruno Casciaro
Deborah Quaglio
Maria Luisa Mangoni
Bruno Botta
Francesca Ghirga
spellingShingle Floriana Cappiello
Maria Rosa Loffredo
Cristina Del Plato
Silvia Cammarone
Bruno Casciaro
Deborah Quaglio
Maria Luisa Mangoni
Bruno Botta
Francesca Ghirga
The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections
Antibiotics
antibiotic resistance
plant secondary metabolites
plant-derived natural products
terpenes
diterpenes
triterpenes
author_facet Floriana Cappiello
Maria Rosa Loffredo
Cristina Del Plato
Silvia Cammarone
Bruno Casciaro
Deborah Quaglio
Maria Luisa Mangoni
Bruno Botta
Francesca Ghirga
author_sort Floriana Cappiello
title The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections
title_short The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections
title_full The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections
title_fullStr The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections
title_full_unstemmed The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections
title_sort revaluation of plant-derived terpenes to fight antibiotic-resistant infections
publisher MDPI AG
series Antibiotics
issn 2079-6382
publishDate 2020-06-01
description The discovery of antibiotics has revolutionized the medicine and treatment of microbial infections. However, the current scenario has highlighted the difficulties in marketing new antibiotics and an exponential increase in the appearance of resistant strains. On the other hand, research in the field of drug-discovery has revaluated the potential of natural products as a unique source for new biologically active molecules and scaffolds for the medicinal chemistry. In this review, we first contextualized the worldwide problem of antibiotic resistance and the importance that natural products of plant origin acquire as a source of new lead compounds. We then focused on terpenes and their potential development as antimicrobials, highlighting those studies that showed an activity against conventional antibiotic-resistant strains.
topic antibiotic resistance
plant secondary metabolites
plant-derived natural products
terpenes
diterpenes
triterpenes
url https://www.mdpi.com/2079-6382/9/6/325
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