Characterizing the relationship between lesion-activation distance using fMRI and verbal measures in brain tumor patients

• Main Authors: Sean P. Riley, Daniel Y. Chu, Veena A. Nair, Mustafa K. Baskaya, John S. Kuo, Mary Elizabeth Meyerand, Vivek Prabhakaran
• Format: Article
• Language: English
• Published: Elsevier 2022-03-01
• Series: Interdisciplinary Neurosurgery
• Subjects: fMRI; Imaging; Tumor; Language
• Online Access: http://www.sciencedirect.com/science/article/pii/S2214751921003030

Functional resonance magnetic imaging (fMRI) allows for identification of eloquent cortex in pre-treatment planning. Previous studies have shown a correlation among lesion to activation distance (LAD) measures and morbidity and mortality. This study investigates the relationship between LAD, well-established language centers (Wernicke’s and Broca’s), and language performance measures. We included a sample population of brain tumor patients that received language fMRI (verbal fluency and sentence verification) for pre-treatment assessment (n = 51). LAD to the nearest language area was measured and divided into groups ≤ 10 mm and > 10 mm. Verbal fluency scores were compared between these groups. Additionally, patients were divided into similar groups based on LAD to either Broca’s or Wernicke’s areas, and the verbal fluency scores and sentence verification accuracy (n = 29) were subsequently compared between groups. Brain tumor patients with LAD ≤ 10 mm to either language area had significantly lower verbal fluency scores (p = 0.028). The difference in verbal fluency scores between groups with LAD ≤ 10 mm and > 10 mm to Wernicke’s area trends toward significance (p = 0.067). The sentence verification accuracy was significantly lower in patients with LAD ≤ 10 mm to either language area (p = 0.039). These findings suggest that there exists a significant relationship between LAD to language centers and measures; greater language deficits are seen when LAD ≤ 10 mm.