Recent advances in the development of nature-derived photocrosslinkable biomaterials for 3D printing in tissue engineering

Abstract Background In recent years, three-dimensional (3D) printing has begun to be widely used in tissue engineering. Natural biomaterials have been employed to overcome the limitations of synthetic polymers. However, their low mechanical strength and poor printability are major disadvantages. Pho...

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Main Authors: Geunho Choi, Hyung Joon Cha
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Biomaterials Research
Subjects:
Online Access:http://link.springer.com/article/10.1186/s40824-019-0168-8
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spelling doaj-c31980de7508451588bc1bd02bf4dc872020-11-25T04:09:53ZengBMCBiomaterials Research2055-71242019-11-012311710.1186/s40824-019-0168-8Recent advances in the development of nature-derived photocrosslinkable biomaterials for 3D printing in tissue engineeringGeunho Choi0Hyung Joon Cha1Department of Chemical Engineering, Pohang University of Science and TechnologyDepartment of Chemical Engineering, Pohang University of Science and TechnologyAbstract Background In recent years, three-dimensional (3D) printing has begun to be widely used in tissue engineering. Natural biomaterials have been employed to overcome the limitations of synthetic polymers. However, their low mechanical strength and poor printability are major disadvantages. Photocrosslinking is the most promising fabrication strategy because it is non-invasive and easy to control light intensity and exposure. In this article, developments of photocrosslinkable natural biomaterials in the field of 3D printing are reviewed. Main body Photocrosslinkable biomaterials can be broadly classified into materials that use ultraviolet (UV) and visible lights. Many natural biomaterials such as gelatin, hydroxyapatite, silk fibroin, and pectin have been modified through acrylation, crosslinked by 365 nm UV light, and 3D printed. Riboflavin could also be used to crosslink and print collagen or decellularized extracellular matrix (dECM). In the case of silk-like aneroin and modified gelatin, crosslinking is possible by forming a dityrosine bond using 452 nm visible light. Conclusion Despite the tremendous researches on the developments of photocrosslinkable 3D printing natural biomaterials, further efforts are necessary to develop source biomaterials with excellent biological functions and sufficient mechanical integrity.http://link.springer.com/article/10.1186/s40824-019-0168-83D printingPhotocrosslinkingBiomaterialsTissue engineering
collection DOAJ
language English
format Article
sources DOAJ
author Geunho Choi
Hyung Joon Cha
spellingShingle Geunho Choi
Hyung Joon Cha
Recent advances in the development of nature-derived photocrosslinkable biomaterials for 3D printing in tissue engineering
Biomaterials Research
3D printing
Photocrosslinking
Biomaterials
Tissue engineering
author_facet Geunho Choi
Hyung Joon Cha
author_sort Geunho Choi
title Recent advances in the development of nature-derived photocrosslinkable biomaterials for 3D printing in tissue engineering
title_short Recent advances in the development of nature-derived photocrosslinkable biomaterials for 3D printing in tissue engineering
title_full Recent advances in the development of nature-derived photocrosslinkable biomaterials for 3D printing in tissue engineering
title_fullStr Recent advances in the development of nature-derived photocrosslinkable biomaterials for 3D printing in tissue engineering
title_full_unstemmed Recent advances in the development of nature-derived photocrosslinkable biomaterials for 3D printing in tissue engineering
title_sort recent advances in the development of nature-derived photocrosslinkable biomaterials for 3d printing in tissue engineering
publisher BMC
series Biomaterials Research
issn 2055-7124
publishDate 2019-11-01
description Abstract Background In recent years, three-dimensional (3D) printing has begun to be widely used in tissue engineering. Natural biomaterials have been employed to overcome the limitations of synthetic polymers. However, their low mechanical strength and poor printability are major disadvantages. Photocrosslinking is the most promising fabrication strategy because it is non-invasive and easy to control light intensity and exposure. In this article, developments of photocrosslinkable natural biomaterials in the field of 3D printing are reviewed. Main body Photocrosslinkable biomaterials can be broadly classified into materials that use ultraviolet (UV) and visible lights. Many natural biomaterials such as gelatin, hydroxyapatite, silk fibroin, and pectin have been modified through acrylation, crosslinked by 365 nm UV light, and 3D printed. Riboflavin could also be used to crosslink and print collagen or decellularized extracellular matrix (dECM). In the case of silk-like aneroin and modified gelatin, crosslinking is possible by forming a dityrosine bond using 452 nm visible light. Conclusion Despite the tremendous researches on the developments of photocrosslinkable 3D printing natural biomaterials, further efforts are necessary to develop source biomaterials with excellent biological functions and sufficient mechanical integrity.
topic 3D printing
Photocrosslinking
Biomaterials
Tissue engineering
url http://link.springer.com/article/10.1186/s40824-019-0168-8
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AT hyungjooncha recentadvancesinthedevelopmentofnaturederivedphotocrosslinkablebiomaterialsfor3dprintingintissueengineering
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