Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population

Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population

Blood metabolites are influenced by a combination of genetic and environmental factors. Here, Yousri and colleagues perform a whole-exome sequencing study in combination with a metabolomics analysis to identify metabolic quantitative trait loci in a Middle Eastern population.

Bibliographic Details
Main Authors: Noha A. Yousri, Khalid A. Fakhro, Amal Robay, Juan L. Rodriguez-Flores, Robert P. Mohney, Hassina Zeriri, Tala Odeh, Sara Abdul Kader, Eman K. Aldous, Gaurav Thareja, Manish Kumar, Alya Al-Shakaki, Omar M. Chidiac, Yasmin A. Mohamoud, Jason G. Mezey, Joel A. Malek, Ronald G. Crystal, Karsten Suhre
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01972-9
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spelling doaj-c31de4379d5747af8230fd50df05087b2021-05-11T09:51:08ZengNature Publishing GroupNature Communications2041-17232018-01-019111310.1038/s41467-017-01972-9Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern populationNoha A. Yousri0Khalid A. Fakhro1Amal Robay2Juan L. Rodriguez-Flores3Robert P. Mohney4Hassina Zeriri5Tala Odeh6Sara Abdul Kader7Eman K. Aldous8Gaurav Thareja9Manish Kumar10Alya Al-Shakaki11Omar M. Chidiac12Yasmin A. Mohamoud13Jason G. Mezey14Joel A. Malek15Ronald G. Crystal16Karsten Suhre17Genetic Medicine, Weill Cornell Medicine-QatarGenetic Medicine, Weill Cornell Medicine-QatarGenetic Medicine, Weill Cornell Medicine-QatarGenetic Medicine, Weill Cornell MedicineMetabolon IncGenetic Medicine, Weill Cornell Medicine-QatarGenetic Medicine, Weill Cornell Medicine-QatarPhysiology and Biophysics, Weill Cornell Medicine-QatarGenomics Core, Weill Cornell Medicine-QatarPhysiology and Biophysics, Weill Cornell Medicine-QatarPhysiology and Biophysics, Weill Cornell Medicine-QatarGenetic Medicine, Weill Cornell Medicine-QatarGenetic Medicine, Weill Cornell Medicine-QatarGenomics Core, Weill Cornell Medicine-QatarGenetic Medicine, Weill Cornell MedicineGenetic Medicine, Weill Cornell Medicine-QatarGenetic Medicine, Weill Cornell MedicinePhysiology and Biophysics, Weill Cornell Medicine-QatarBlood metabolites are influenced by a combination of genetic and environmental factors. Here, Yousri and colleagues perform a whole-exome sequencing study in combination with a metabolomics analysis to identify metabolic quantitative trait loci in a Middle Eastern population.https://doi.org/10.1038/s41467-017-01972-9
collection DOAJ
language English
format Article
sources DOAJ
author Noha A. Yousri
Khalid A. Fakhro
Amal Robay
Juan L. Rodriguez-Flores
Robert P. Mohney
Hassina Zeriri
Tala Odeh
Sara Abdul Kader
Eman K. Aldous
Gaurav Thareja
Manish Kumar
Alya Al-Shakaki
Omar M. Chidiac
Yasmin A. Mohamoud
Jason G. Mezey
Joel A. Malek
Ronald G. Crystal
Karsten Suhre
spellingShingle Noha A. Yousri
Khalid A. Fakhro
Amal Robay
Juan L. Rodriguez-Flores
Robert P. Mohney
Hassina Zeriri
Tala Odeh
Sara Abdul Kader
Eman K. Aldous
Gaurav Thareja
Manish Kumar
Alya Al-Shakaki
Omar M. Chidiac
Yasmin A. Mohamoud
Jason G. Mezey
Joel A. Malek
Ronald G. Crystal
Karsten Suhre
Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population
Nature Communications
author_facet Noha A. Yousri
Khalid A. Fakhro
Amal Robay
Juan L. Rodriguez-Flores
Robert P. Mohney
Hassina Zeriri
Tala Odeh
Sara Abdul Kader
Eman K. Aldous
Gaurav Thareja
Manish Kumar
Alya Al-Shakaki
Omar M. Chidiac
Yasmin A. Mohamoud
Jason G. Mezey
Joel A. Malek
Ronald G. Crystal
Karsten Suhre
author_sort Noha A. Yousri
title Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population
title_short Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population
title_full Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population
title_fullStr Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population
title_full_unstemmed Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population
title_sort whole-exome sequencing identifies common and rare variant metabolic qtls in a middle eastern population
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-01-01
description Blood metabolites are influenced by a combination of genetic and environmental factors. Here, Yousri and colleagues perform a whole-exome sequencing study in combination with a metabolomics analysis to identify metabolic quantitative trait loci in a Middle Eastern population.
url https://doi.org/10.1038/s41467-017-01972-9
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