Genetic Profile in Genes Associated with Cardiorespiratory Fitness in Elite Spanish Male Endurance Athletes
Background: most of the research concerning the influence of genetics on endurance performance has been carried out by investigating target genes separately. However, endurance performance is a complex trait that can stem from the interaction of several genes. The objective of this study was to comp...
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doaj-c324202c4bbe409b999166c575c122222021-08-26T13:47:01ZengMDPI AGGenes2073-44252021-08-01121230123010.3390/genes12081230Genetic Profile in Genes Associated with Cardiorespiratory Fitness in Elite Spanish Male Endurance AthletesDavid Varillas-Delgado0Juan José Tellería Orriols1Juan Del Coso2Faculty of Health Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcon, 28223 Madrid, SpainFaculty of Medicine, University of Valladolid, 47003 Valladolid, SpainCentre for Sport Studies, Rey Juan Carlos University, 28008 Fuenlabrada, SpainBackground: most of the research concerning the influence of genetics on endurance performance has been carried out by investigating target genes separately. However, endurance performance is a complex trait that can stem from the interaction of several genes. The objective of this study was to compare the frequencies of polymorphisms in target genes involving cardiorespiratory functioning in elite endurance athletes vs. non-athlete controls. Methods: genotypic frequencies were determined in 123 elite endurance athletes and in 122 non-athletes. Genotyping of <i>ACE</i> (rs4340), <i>NOS3</i> (rs2070744 and rs1799983), <i>ADRA2a</i> (rs1800544 and rs553668), <i>ADRB2</i> (rs1042713 and rs1042714), and BDKRB2 (rs5810761) was performed by polymerase chain reaction. The total genotype score (TGS: from 0 to 100 arbitrary units; a.u.) was calculated from the genotype score in each polymorphism. Results: the mean TGS in non-athletes (47.72 ± 11.29 a.u.) was similar to elite endurance athletes (46.54 ± 11.32 a.u., <i>p</i> = 0.415). The distribution of TGS frequencies were also similar in non-athletes and elite endurance athletes (<i>p</i> = 0.333). There was no TGS cut-off point to discriminate being elite endurance athletes. Conclusions: the genetic profile in the selected genes was similar in elite endurance athletes and in controls, suggesting that the combination of these genes does not determine endurance performance.https://www.mdpi.com/2073-4425/12/8/1230endurancephysical performancesports performancegenotype score |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David Varillas-Delgado Juan José Tellería Orriols Juan Del Coso |
spellingShingle |
David Varillas-Delgado Juan José Tellería Orriols Juan Del Coso Genetic Profile in Genes Associated with Cardiorespiratory Fitness in Elite Spanish Male Endurance Athletes Genes endurance physical performance sports performance genotype score |
author_facet |
David Varillas-Delgado Juan José Tellería Orriols Juan Del Coso |
author_sort |
David Varillas-Delgado |
title |
Genetic Profile in Genes Associated with Cardiorespiratory Fitness in Elite Spanish Male Endurance Athletes |
title_short |
Genetic Profile in Genes Associated with Cardiorespiratory Fitness in Elite Spanish Male Endurance Athletes |
title_full |
Genetic Profile in Genes Associated with Cardiorespiratory Fitness in Elite Spanish Male Endurance Athletes |
title_fullStr |
Genetic Profile in Genes Associated with Cardiorespiratory Fitness in Elite Spanish Male Endurance Athletes |
title_full_unstemmed |
Genetic Profile in Genes Associated with Cardiorespiratory Fitness in Elite Spanish Male Endurance Athletes |
title_sort |
genetic profile in genes associated with cardiorespiratory fitness in elite spanish male endurance athletes |
publisher |
MDPI AG |
series |
Genes |
issn |
2073-4425 |
publishDate |
2021-08-01 |
description |
Background: most of the research concerning the influence of genetics on endurance performance has been carried out by investigating target genes separately. However, endurance performance is a complex trait that can stem from the interaction of several genes. The objective of this study was to compare the frequencies of polymorphisms in target genes involving cardiorespiratory functioning in elite endurance athletes vs. non-athlete controls. Methods: genotypic frequencies were determined in 123 elite endurance athletes and in 122 non-athletes. Genotyping of <i>ACE</i> (rs4340), <i>NOS3</i> (rs2070744 and rs1799983), <i>ADRA2a</i> (rs1800544 and rs553668), <i>ADRB2</i> (rs1042713 and rs1042714), and BDKRB2 (rs5810761) was performed by polymerase chain reaction. The total genotype score (TGS: from 0 to 100 arbitrary units; a.u.) was calculated from the genotype score in each polymorphism. Results: the mean TGS in non-athletes (47.72 ± 11.29 a.u.) was similar to elite endurance athletes (46.54 ± 11.32 a.u., <i>p</i> = 0.415). The distribution of TGS frequencies were also similar in non-athletes and elite endurance athletes (<i>p</i> = 0.333). There was no TGS cut-off point to discriminate being elite endurance athletes. Conclusions: the genetic profile in the selected genes was similar in elite endurance athletes and in controls, suggesting that the combination of these genes does not determine endurance performance. |
topic |
endurance physical performance sports performance genotype score |
url |
https://www.mdpi.com/2073-4425/12/8/1230 |
work_keys_str_mv |
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