High prevalence of autoantibodies against monomeric C reactive protein (CRP) in children with PFAPA syndrome

PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome is an autoinflammatory disorder of unknown etiology. The aim of our study was to evaluate whether the presence of anti-mCRP autoantibodies (anti-mCRP) might possibly contribute to systemic inflammation during PFAPA...

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Main Authors:	Kraszewska-Glomba Barbara, Myszka Marta, Krajewska Magdalena, Szenborn Leszek
Format:	Article
Language:	English
Published:	Society of Medical Biochemists of Serbia, Belgrade 2018-01-01
Series:	Journal of Medical Biochemistry
Subjects:	anti-crp pfapa periodic fevers autoimmune diseases
Online Access:	https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2018/1452-82581804507K.pdf

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record_format	Article
spelling	doaj-c326eb2bfe47430c8d50b7e08290ec872020-11-25T02:09:59ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662018-01-013745075091452-82581804507KHigh prevalence of autoantibodies against monomeric C reactive protein (CRP) in children with PFAPA syndromeKraszewska-Glomba Barbara0Myszka Marta1Krajewska Magdalena2Szenborn Leszek3Wroclaw Medical University, Department and Clinic of Paediatric Infectious Diseases, Wroclaw, PolandWroclaw Medical University, Faculty of Postgraduate Medical Training, Department and Clinic of Nephrology and Transplantation Medicine, Wroclaw, PolandWroclaw Medical University, Faculty of Postgraduate Medical Training, Department and Clinic of Nephrology and Transplantation Medicine, Wroclaw, PolandWroclaw Medical University, Department and Clinic of Paediatric Infectious Diseases, Wroclaw, PolandPFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome is an autoinflammatory disorder of unknown etiology. The aim of our study was to evaluate whether the presence of anti-mCRP autoantibodies (anti-mCRP) might possibly contribute to systemic inflammation during PFAPA flares. We carried out anti-mCRP testing (in-house ELISA) in a single-center, prospective cohort of 30 PFAPA patients (12 girls). We found a high prevalence (43.3%) of anti-mCRP antibodies in PFAPA patients during their febrile episodes, which implies the possible involvement of anti-mCRP antibodies in PFAPA pathogenesis.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2018/1452-82581804507K.pdfanti-crp pfapaperiodic feversautoimmune diseases
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kraszewska-Glomba Barbara Myszka Marta Krajewska Magdalena Szenborn Leszek
spellingShingle	Kraszewska-Glomba Barbara Myszka Marta Krajewska Magdalena Szenborn Leszek High prevalence of autoantibodies against monomeric C reactive protein (CRP) in children with PFAPA syndrome Journal of Medical Biochemistry anti-crp pfapa periodic fevers autoimmune diseases
author_facet	Kraszewska-Glomba Barbara Myszka Marta Krajewska Magdalena Szenborn Leszek
author_sort	Kraszewska-Glomba Barbara
title	High prevalence of autoantibodies against monomeric C reactive protein (CRP) in children with PFAPA syndrome
title_short	High prevalence of autoantibodies against monomeric C reactive protein (CRP) in children with PFAPA syndrome
title_full	High prevalence of autoantibodies against monomeric C reactive protein (CRP) in children with PFAPA syndrome
title_fullStr	High prevalence of autoantibodies against monomeric C reactive protein (CRP) in children with PFAPA syndrome
title_full_unstemmed	High prevalence of autoantibodies against monomeric C reactive protein (CRP) in children with PFAPA syndrome
title_sort	high prevalence of autoantibodies against monomeric c reactive protein (crp) in children with pfapa syndrome
publisher	Society of Medical Biochemists of Serbia, Belgrade
series	Journal of Medical Biochemistry
issn	1452-8258 1452-8266
publishDate	2018-01-01
description	PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome is an autoinflammatory disorder of unknown etiology. The aim of our study was to evaluate whether the presence of anti-mCRP autoantibodies (anti-mCRP) might possibly contribute to systemic inflammation during PFAPA flares. We carried out anti-mCRP testing (in-house ELISA) in a single-center, prospective cohort of 30 PFAPA patients (12 girls). We found a high prevalence (43.3%) of anti-mCRP antibodies in PFAPA patients during their febrile episodes, which implies the possible involvement of anti-mCRP antibodies in PFAPA pathogenesis.
topic	anti-crp pfapa periodic fevers autoimmune diseases
url	https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2018/1452-82581804507K.pdf
work_keys_str_mv	AT kraszewskaglombabarbara highprevalenceofautoantibodiesagainstmonomericcreactiveproteincrpinchildrenwithpfapasyndrome AT myszkamarta highprevalenceofautoantibodiesagainstmonomericcreactiveproteincrpinchildrenwithpfapasyndrome AT krajewskamagdalena highprevalenceofautoantibodiesagainstmonomericcreactiveproteincrpinchildrenwithpfapasyndrome AT szenbornleszek highprevalenceofautoantibodiesagainstmonomericcreactiveproteincrpinchildrenwithpfapasyndrome
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High prevalence of autoantibodies against monomeric C reactive protein (CRP) in children with PFAPA syndrome

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