EXPRESS METHOD FOR DETERMINATION OF ENALAPRIL AND ENALAPRILAT IN HUMAN SERUM BY HPLC-MS/MS
The express method for simultaneous determination of enalapril and enalaprilat in human serum using HPLC-MS/MS is proposed. A simple sample preparation procedure, short analysis time, and a wide analytical range for both analytes (5.00 to 250.00 ng/mL) characterize this method. This technique is use...
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/173 |
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doaj-c32b8394f931454499f4dff31e8bfdc62021-07-28T13:06:54ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0104184189173EXPRESS METHOD FOR DETERMINATION OF ENALAPRIL AND ENALAPRILAT IN HUMAN SERUM BY HPLC-MS/MST. A. Rodina0E. S. Melnikov1S. A. Belkov2A. V. Sokolov3A. B. Prokofiev4A. S. Sivkov5Scientific Center for Expertise of Medicinal products of the Ministry of Health; The Moscow Department of Health I.V. Davydovsky City Clinical HospitalThe Moscow Department of Health I.V. Davydovsky City Clinical Hospital; I.M. Sechenov First Moscow State Medical UniversityScientific Center for Expertise of Medicinal products of the Ministry of Health; The Moscow Department of Health I.V. Davydovsky City Clinical Hospital; I.M. Sechenov First Moscow State Medical UniversityScientific Center for Expertise of Medicinal products of the Ministry of Health; I.M. Sechenov First Moscow State Medical UniversityScientific Center for Expertise of Medicinal products of the Ministry of Health; The Moscow Department of Health I.V. Davydovsky City Clinical Hospital; I.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical UniversityThe express method for simultaneous determination of enalapril and enalaprilat in human serum using HPLC-MS/MS is proposed. A simple sample preparation procedure, short analysis time, and a wide analytical range for both analytes (5.00 to 250.00 ng/mL) characterize this method. This technique is useful for carrying out routine research, such as therapeutic drug monitoring, bioequivalence studies and evaluation of the interchangeability of enalapril drug products.https://www.pharmjournal.ru/jour/article/view/173enalaprilenalaprilathplc-ms/mstherapeutic drug monitoringbioequivalenceinterchangeability |
| collection |
DOAJ |
| language |
Russian |
| format |
Article |
| sources |
DOAJ |
| author |
T. A. Rodina E. S. Melnikov S. A. Belkov A. V. Sokolov A. B. Prokofiev A. S. Sivkov |
| spellingShingle |
T. A. Rodina E. S. Melnikov S. A. Belkov A. V. Sokolov A. B. Prokofiev A. S. Sivkov EXPRESS METHOD FOR DETERMINATION OF ENALAPRIL AND ENALAPRILAT IN HUMAN SERUM BY HPLC-MS/MS Разработка и регистрация лекарственных средств enalapril enalaprilat hplc-ms/ms therapeutic drug monitoring bioequivalence interchangeability |
| author_facet |
T. A. Rodina E. S. Melnikov S. A. Belkov A. V. Sokolov A. B. Prokofiev A. S. Sivkov |
| author_sort |
T. A. Rodina |
| title |
EXPRESS METHOD FOR DETERMINATION OF ENALAPRIL AND ENALAPRILAT IN HUMAN SERUM BY HPLC-MS/MS |
| title_short |
EXPRESS METHOD FOR DETERMINATION OF ENALAPRIL AND ENALAPRILAT IN HUMAN SERUM BY HPLC-MS/MS |
| title_full |
EXPRESS METHOD FOR DETERMINATION OF ENALAPRIL AND ENALAPRILAT IN HUMAN SERUM BY HPLC-MS/MS |
| title_fullStr |
EXPRESS METHOD FOR DETERMINATION OF ENALAPRIL AND ENALAPRILAT IN HUMAN SERUM BY HPLC-MS/MS |
| title_full_unstemmed |
EXPRESS METHOD FOR DETERMINATION OF ENALAPRIL AND ENALAPRILAT IN HUMAN SERUM BY HPLC-MS/MS |
| title_sort |
express method for determination of enalapril and enalaprilat in human serum by hplc-ms/ms |
| publisher |
LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| series |
Разработка и регистрация лекарственных средств |
| issn |
2305-2066 2658-5049 |
| publishDate |
2019-01-01 |
| description |
The express method for simultaneous determination of enalapril and enalaprilat in human serum using HPLC-MS/MS is proposed. A simple sample preparation procedure, short analysis time, and a wide analytical range for both analytes (5.00 to 250.00 ng/mL) characterize this method. This technique is useful for carrying out routine research, such as therapeutic drug monitoring, bioequivalence studies and evaluation of the interchangeability of enalapril drug products. |
| topic |
enalapril enalaprilat hplc-ms/ms therapeutic drug monitoring bioequivalence interchangeability |
| url |
https://www.pharmjournal.ru/jour/article/view/173 |
| work_keys_str_mv |
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1721276905085206528 |