Strain dependent variation of immune responses to A. fumigatus: definition of pathogenic species.
For over a century microbiologists and immunologist have categorized microorganisms as pathogenic or non-pathogenic species or genera. This definition, clearly relevant at the strain and species level for most bacteria, where differences in virulence between strains of a particular species are well...
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doaj-c3443a8d2f4c431da2e866cc3c56d8f12020-11-25T02:42:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5665110.1371/journal.pone.0056651Strain dependent variation of immune responses to A. fumigatus: definition of pathogenic species.Lisa RizzettoGloria GiovanniniMichael BromleyPaul BowyerLuigina RomaniDuccio CavalieriFor over a century microbiologists and immunologist have categorized microorganisms as pathogenic or non-pathogenic species or genera. This definition, clearly relevant at the strain and species level for most bacteria, where differences in virulence between strains of a particular species are well known, has never been probed at the strain level in fungal species. Here, we tested the immune reactivity and the pathogenic potential of a collection of strains from Aspergillus spp, a fungus that is generally considered pathogenic in immuno-compromised hosts. Our results show a wide strain-dependent variation of the immune response elicited indicating that different isolates possess diverse virulence and infectivity. Thus, the definition of markers of inflammation or pathogenicity cannot be generalized. The profound understanding of the molecular mechanisms subtending the different immune responses will result solely from the comparative study of strains with extremely diverse properties.http://europepmc.org/articles/PMC3575482?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lisa Rizzetto Gloria Giovannini Michael Bromley Paul Bowyer Luigina Romani Duccio Cavalieri |
spellingShingle |
Lisa Rizzetto Gloria Giovannini Michael Bromley Paul Bowyer Luigina Romani Duccio Cavalieri Strain dependent variation of immune responses to A. fumigatus: definition of pathogenic species. PLoS ONE |
author_facet |
Lisa Rizzetto Gloria Giovannini Michael Bromley Paul Bowyer Luigina Romani Duccio Cavalieri |
author_sort |
Lisa Rizzetto |
title |
Strain dependent variation of immune responses to A. fumigatus: definition of pathogenic species. |
title_short |
Strain dependent variation of immune responses to A. fumigatus: definition of pathogenic species. |
title_full |
Strain dependent variation of immune responses to A. fumigatus: definition of pathogenic species. |
title_fullStr |
Strain dependent variation of immune responses to A. fumigatus: definition of pathogenic species. |
title_full_unstemmed |
Strain dependent variation of immune responses to A. fumigatus: definition of pathogenic species. |
title_sort |
strain dependent variation of immune responses to a. fumigatus: definition of pathogenic species. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
For over a century microbiologists and immunologist have categorized microorganisms as pathogenic or non-pathogenic species or genera. This definition, clearly relevant at the strain and species level for most bacteria, where differences in virulence between strains of a particular species are well known, has never been probed at the strain level in fungal species. Here, we tested the immune reactivity and the pathogenic potential of a collection of strains from Aspergillus spp, a fungus that is generally considered pathogenic in immuno-compromised hosts. Our results show a wide strain-dependent variation of the immune response elicited indicating that different isolates possess diverse virulence and infectivity. Thus, the definition of markers of inflammation or pathogenicity cannot be generalized. The profound understanding of the molecular mechanisms subtending the different immune responses will result solely from the comparative study of strains with extremely diverse properties. |
url |
http://europepmc.org/articles/PMC3575482?pdf=render |
work_keys_str_mv |
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