Hypoglycemia and death in mice following experimental exposure to an extract of Trogia venenata mushrooms.
BACKGROUND: Clusters of sudden unexplained death (SUD) in Yunnan Province, China, have been linked to eating Trogia venenata mushrooms. We evaluated the toxic effect of this mushroom on mice. METHODS: We prepared extracts of fresh T. venenata and Laccaria vinaceoavellanea mushrooms collected from th...
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2012-01-01
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doaj-c3485792097643acb58c0b9aa4c5543a2020-11-24T21:26:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0176e3871210.1371/journal.pone.0038712Hypoglycemia and death in mice following experimental exposure to an extract of Trogia venenata mushrooms.GuoQing ShiJun HeTao ShenRobert E FontaineLin YangZhongYu ZhouHong GaoYanFeng XuChuan QinZhuLiang YangJiKai LiuWenLi HuangGuang ZengBACKGROUND: Clusters of sudden unexplained death (SUD) in Yunnan Province, China, have been linked to eating Trogia venenata mushrooms. We evaluated the toxic effect of this mushroom on mice. METHODS: We prepared extracts of fresh T. venenata and Laccaria vinaceoavellanea mushrooms collected from the environs of a village that had SUD. We randomly allocated mice into treatment groups and administered mushroom extracts at doses ranging from 500 to 3500 mg/kg and water (control) via a gavage needle. We observed mice for mortality for 7 days after a 3500 mg/kg dose and for 24 hours after doses from 500 to 3000 mg/kg. We determined biochemical markers from serum two hours after a 2000 mg/kg dose. RESULTS: Ten mice fed T. venenata extract (3500 mg/kg) died by five hours whereas all control mice (L. vinaceoavellanea extract and water) survived the seven-day observation period. All mice died by five hours after exposure to single doses of T. venenata extract ranging from 1500 to 3000 mg/kg, while the four mice exposed to a 500 mg/kg dose all survived. Mice fed 2000 mg/kg of T. venenata extract developed profound hypoglycemia (median= 0.66 mmol/L) two hours after exposure. DISCUSSION: Hypoglycemia and death within hours of exposure, a pattern unique among mushroom toxicity, characterize T. venenata poisoning.http://europepmc.org/articles/PMC3380013?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
GuoQing Shi Jun He Tao Shen Robert E Fontaine Lin Yang ZhongYu Zhou Hong Gao YanFeng Xu Chuan Qin ZhuLiang Yang JiKai Liu WenLi Huang Guang Zeng |
spellingShingle |
GuoQing Shi Jun He Tao Shen Robert E Fontaine Lin Yang ZhongYu Zhou Hong Gao YanFeng Xu Chuan Qin ZhuLiang Yang JiKai Liu WenLi Huang Guang Zeng Hypoglycemia and death in mice following experimental exposure to an extract of Trogia venenata mushrooms. PLoS ONE |
author_facet |
GuoQing Shi Jun He Tao Shen Robert E Fontaine Lin Yang ZhongYu Zhou Hong Gao YanFeng Xu Chuan Qin ZhuLiang Yang JiKai Liu WenLi Huang Guang Zeng |
author_sort |
GuoQing Shi |
title |
Hypoglycemia and death in mice following experimental exposure to an extract of Trogia venenata mushrooms. |
title_short |
Hypoglycemia and death in mice following experimental exposure to an extract of Trogia venenata mushrooms. |
title_full |
Hypoglycemia and death in mice following experimental exposure to an extract of Trogia venenata mushrooms. |
title_fullStr |
Hypoglycemia and death in mice following experimental exposure to an extract of Trogia venenata mushrooms. |
title_full_unstemmed |
Hypoglycemia and death in mice following experimental exposure to an extract of Trogia venenata mushrooms. |
title_sort |
hypoglycemia and death in mice following experimental exposure to an extract of trogia venenata mushrooms. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
BACKGROUND: Clusters of sudden unexplained death (SUD) in Yunnan Province, China, have been linked to eating Trogia venenata mushrooms. We evaluated the toxic effect of this mushroom on mice. METHODS: We prepared extracts of fresh T. venenata and Laccaria vinaceoavellanea mushrooms collected from the environs of a village that had SUD. We randomly allocated mice into treatment groups and administered mushroom extracts at doses ranging from 500 to 3500 mg/kg and water (control) via a gavage needle. We observed mice for mortality for 7 days after a 3500 mg/kg dose and for 24 hours after doses from 500 to 3000 mg/kg. We determined biochemical markers from serum two hours after a 2000 mg/kg dose. RESULTS: Ten mice fed T. venenata extract (3500 mg/kg) died by five hours whereas all control mice (L. vinaceoavellanea extract and water) survived the seven-day observation period. All mice died by five hours after exposure to single doses of T. venenata extract ranging from 1500 to 3000 mg/kg, while the four mice exposed to a 500 mg/kg dose all survived. Mice fed 2000 mg/kg of T. venenata extract developed profound hypoglycemia (median= 0.66 mmol/L) two hours after exposure. DISCUSSION: Hypoglycemia and death within hours of exposure, a pattern unique among mushroom toxicity, characterize T. venenata poisoning. |
url |
http://europepmc.org/articles/PMC3380013?pdf=render |
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