Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects

• Main Authors: Shaun R Patel, Todd M Herrington, Sameer A Sheth, Matthew Mian, Sarah K Bick, Jimmy C Yang, Alice W Flaherty, Michael J Frank, Alik S Widge, Darin Dougherty, Emad N Eskandar
• Format: Article
• Language: English
• Published: eLife Sciences Publications Ltd 2018-09-01
• Series: eLife
• Subjects: subthalamic nucleus; neurophysiology; fMRI; human; decision-making; deep brain stimulation
• Online Access: https://elifesciences.org/articles/36460

The subthalamic nucleus (STN) is a small almond-shaped subcortical structure classically known for its role in motor inhibition through the indirect pathway within the basal ganglia. Little is known about the role of the STN in mediating cognitive functions in humans. Here, we explore the role of the STN in human subjects making decisions under conditions of uncertainty using single-neuron recordings and intermittent deep brain stimulation (DBS) during a financial decision-making task. Intraoperative single-neuronal data from the STN reveals that on high-uncertainty trials, spiking activity encodes the upcoming decision within a brief (500 ms) temporal window during the choice period, prior to the manifestation of the choice. Application of intermittent DBS selectively prior to the choice period alters decisions and biases subject behavior towards conservative wagers.