Differences in the expression of selected genes associated with cell stress response in a PTSD patient and in healthy individuals – a case study

• Main Authors: Anna Rasmus, Paweł Półrola, Jolanta Góral-Półrola, Małgorzata Żychowska, Andrzej Mirski, Henryk Knapik
• Format: Article
• Language: English
• Published: Institute of Rural Health 2017-06-01
• Series: Annals of Agricultural and Environmental Medicine
• Subjects: cell stress; PTSD patient; expression of selected genes; healthy individuals
• Online Access: http://www.journalssystem.com/aaem/Differences-in-the-expression-of-selected-genes-associated-with-cell-stress-response-in-a-PTSD-patient-and-in-healthy-individuals-a-case-study,74711,0,2.html
• ISSN: 1232-1966; 1898-2263

Objective The aim of the study was determination of the level in expression genes associated with cell stress response in a patient with PTSD. Case study A 57-year-old PTSD patient, A.P., was the subject of the study. Blood samples were taken from the ulnar vein to assess the relative expression of the tested genes in leukocytes via a quantitative reverse transcription polymerase chain reaction (qRT-PCR). Results A considerably decreased level in the expression HSF-1, NF-kB, Hif-1 and IL6 m-RNA was observed in the patient when compared to the control group. A low expression in HSPA1A, HSPB1, IL10 and CRP m-RNA compared with the control group was also noted. Conclusions It is possible that the lower level of transcriptional factors: HSF-1, NF-kB and Hif-1 as well as IL6 m-RNA may be associated with the effect of the PTSD patient’s treatment.